MDMA Supplementation

Comment · Wed, August 21, 2013 · 2 pts

I would not suggest rolling multiple days in a row. You are going to be causing much more damage than one roll, and your effects will not be even close to the same. I would suggest finding a different substance for days

Comment · Wed, August 21, 2013 · 3 pts

Usually I start with MDMA on day one, then move to other substances for the other days. I am going to Vegas on a bachelor party in a couple weeks. Night one will be MDMA, the next day will be kratom, that night will be e

Comment · Fri, August 23, 2013 · 1 pts

Perhaps some. However, I would need to do more research. ALA is damn good, so I am not sure we need to add another ROS scavenger in there. We have to be careful of antioxidants turning pro-oxidant, as they can sometimes

Comment · Fri, August 23, 2013 · 1 pts

I just eat a big sushi dinner before my rolls. Salmon has the highest concentration of astaxanthin in nature.

Comment · Wed, August 28, 2013 · 3 pts

I've already commented on this a few times. However, I comment too much to be able to go back and find them. You most definitely want to stop **ALL** metabolism. Saying that you should take that step out because it slow

Comment · Thu, August 29, 2013 · 1 pts

Yes, because you want to excrete the MDMA unchanged before it has a chance to metabolize. EGCG helps with the vasopressin release.

Comment · Fri, August 30, 2013 · 2 pts

Piperine has very little MAOI inhibition. It's around 1,000 times less than segeligine.

Comment · Fri, August 30, 2013 · 1 pts

Milk thistle should work somewhat as well. I am not sure how potent it is, though. I am a little concerned about the piperine, as I do not know how much it will increase peak plasma levels. There is really only one way t

Comment · Mon, September 2, 2013 · 2 pts

Keep in mind that NAC need to be taken BEFORE any alcohol is consumed, or it can turn pro-oxidant. Don't take it at he end of the night.

Comment · Mon, September 2, 2013 · 1 pts

I usually redose at 1hr in, with half my initial dose. That gives me 6 hours. No redose and it's usually 4-5 hours.

Comment · Mon, September 2, 2013 · 1 pts

Hey, I did the piperine thing this weekend. I am not sure what happened, but it must have blocked an absorption pathway. It took over 2 hours for my MDMA to hit on an empty stomach, then only lasted 2 hours or so. I have

Comment · Tue, September 3, 2013 · 2 pts

Yeah, it was completely opposite of what I thought would happen. Very strange... Ohh, and I got a little sadness 40 or so hours after my roll, which lasted a couple hours. That never happens to me.

Comment · Tue, September 3, 2013 · 1 pts

I'd definitely hold off till I figure out what happened.

Comment · Thu, September 5, 2013 · 2 pts

> astaxanthin I don't see anything obvious that would be harmful. It could be a good addition as an antioxidant. I'm not certain of it's effect on the roll experience, though.

Comment · Fri, February 7, 2014 · 3 pts

I think I figured out it was an interaction with the SAMe that I had earlier in the day. I had been on a SAMe regimen for a few weeks, and did not think of possible interactions. Since SAMe affects the serotonin system,

Comment · Sat, February 8, 2014 · 1 pts

I don't think anyone downvoted, but you are welcome. Be safe and have fun!

Comment · Tue, November 16, 2021 · 2 pts

Depends on the ALA form. ALA is susceptible to heat. Racemic is pretty stable, but R-ALA is not. Na-R-ALA is much more stable, though. You need it in the sodium salt form. ALCAR is super stable from all our testing.

Comment · Tue, November 16, 2021 · 2 pts

Yeah, that is the sodium salt, so it is stable.

Comment · Wed, November 17, 2021 · 1 pts

Tums reduces the acids that reach the duodenum, which helps improve absorption. https://www.ncbi.nlm.nih.gov/books/NBK526049/ >The antacids reduce the acid reaching the duodenum by neutralizing the acid present in the

Comment · Sat, November 20, 2021 · 3 pts

I think it is just a mixture of the aftereffects of MDMA paired with the 5-HTP helping to keep serotonin levels higher. That crash from MDMA is partly due to damage and down-regulation, but a big part of it is the reduct

Comment · Fri, December 31, 2021 · 1 pts

Right before is usually 15-30min before. You can take them all together.

Comment · Sun, March 20, 2022 · 11 pts

I have not made any official updates, no. I'd have to really sit down and think about it. There are certainly things I would change with the knowledge I have now, but it would take some brainstorming to settle on a regim

Comment · Tue, April 12, 2022 · 2 pts

It's good to take the magnesium, CoQ10, and vitamin C every day leading up to it. Magnesium takes time to build up, and both CoQ10 and vitamin C are good daily.

Comment · Fri, April 29, 2022 · 1 pts

Hmmm, headaches in that scenario are likely from 5-HT2B activation. https://opus4.kobv.de/opus4-fau/files/11219/Segelcke_putative.pdf Preventing that might be difficult. I know some people have luck using CoQ10 to lowe

Comment · Wed, May 18, 2022 · 1 pts

I wouldn't, as there is some weird glutathione conjugation happening that we don't fully understand yet. https://www.sciencedirect.com/science/article/abs/pii/S0006899303033195

Comment · Tue, May 24, 2022 · 2 pts

Glutathione is your body's main natural antioxidant. It's a great thing to increase. However, there is just an acute thing with MDMA conjugation that we don't fully understand yet. I think it is fine before and after rol

Comment · Fri, May 27, 2022 · 1 pts

I use our Micromag almost exclusively these days. It's just way better for me than any other form.

Comment · Fri, May 27, 2022 · 1 pts

Let me know how it goes!

Comment · Tue, June 7, 2022 · 2 pts

The electrolytes are for the water intake, as MDMA can throw your electrolyte balance off and cause a bunch of issues. Plus, people can overheat on MDMA, so they tend to either drink not enough water, which is bad, or to

Comment · Tue, June 7, 2022 · 2 pts

Yeah, mineral water would be better than plain water. However, for most people taking either an electrolyte capsule or a dissolving tablet/packet for their water will be easier.

Comment · Wed, June 8, 2022 · 1 pts

3 months, if you want to keep tolerance at bay.

Comment · Wed, June 8, 2022 · 4 pts

For a normal person, yes. I would suggest our saffron over 5-HTP for daily use. However, in the case of post-MDMA effects, the issue is a reduction in the tryptophan hydroxylase enzyme. The best way to bypass that is to

Comment · Fri, June 10, 2022 · 3 pts

Inhibiting CYP3A4 and CYP2D6 will both increase MDMA serum levels. This is why you have to be careful, as it might make the effects too strong. Inhibiting the metabolism is good to prevent the toxic metabolites. You just

Comment · Sun, June 12, 2022 · 1 pts

Yes, those would be good to help with the vasoconstriction.

Comment · Sun, June 12, 2022 · 3 pts

It will be mild and reversible, like valerian and passionflower.

Comment · Sun, June 12, 2022 · 1 pts

I mean, I would avoid it out of an abundance of caution. It's probably not a massive risk, but better safe than sorry.

Comment · Tue, June 21, 2022 · 2 pts

An acute dose of grapeseed extract will not reduce estrogen by 80%...

Comment · Thu, July 21, 2022 · 1 pts

I would focus on things that increase BDNF, NGF, CNTF, and GDNF. This is what I would suggest. * Andrographis * 4'DMA-7,8-DHF * Polygala * Lion's Mane * Poria Then I would add in some everyday staples that you are like

Comment · Thu, July 21, 2022 · 4 pts

Lion's mane is a great mushroom for before and after. I am not sure how it would affect during, though.