Comment · Wed, August 21, 2013
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
olivercroke · 2 points
I'm planning on doing MDMA three days in a row at a festival. I know you'll highly advise against it but I will probably go ahead anyway. I've bought some Piracetam (advise on dosage with this?) and 5-HTP and I'm going to try and acquire as many of the other supplements as possible. I'm just not sure on when I should start my supplementation of 5-HTP. Say I do my 1st roll on Friday, then 2nd roll on Saturday and final roll on Sunday would you suggest taking 100mg of 5-HTP after my 1st roll that night and 100mg every night thereafter or would you suggest waiting until after my 3rd roll on Sunday night before starting 5-HTP supplementation? My second question is I have some 300mg Mg pills that consist of MgO MgCO3 and Mg Stearate. It doesn't say in what ratios the pills contain of each (I'm guessing MgO is the highest as it's easily abundant and you said the worst) but was wondering your opinion on bio availability of stearate and carbonate bound forms? Sorry to reply to this comment but it was the only way I could see how to post as it's my first post as I signed up to reddit just to talk to you. And you sir are a saint for taking all this time to put together this information and keeping in contact with people to educate and keep them safe, I myself appreciate it huuugely and I haven't even started the regimen yet.
u/MisterYouAreSoDumb
I would not suggest rolling multiple days in a row. You are going to be causing much more damage than one roll, and your effects will not be even close to the same. I would suggest finding a different substance for days 2 and 3.
Also, don't take 5-HTP with your MDMA. It's for after, to recover.
Magnesium carbonate will only have a bioavailability of 30%, compared to 80% with glycinate. It's better than nothing, though.
I would highly suggest rethinking rolling 3 days in a row. Not even my supplementation plan can protect completely from that.