Comment · Tue, May 24, 2022
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
bob2804 · 1 points
What is the reason it works for a pretty large group then? I know it’s not scientifically proven that it does help but there is a couple studies including rats that shows it protects and restores the brain. (Doesn’t mean it works for humans to)
u/MisterYouAreSoDumb
Glutathione is your body's main natural antioxidant. It's a great thing to increase. However, there is just an acute thing with MDMA conjugation that we don't fully understand yet. I think it is fine before and after rolling, but not during. I personally just take reduced glutathione every day, and that keeps my levels stable.