Comment · Wed, June 8, 2022
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
_______________________________________________________
Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
lugaresxcomunes · 2 points
Hello! Thank you for this! Would Saffron be a good option instead of 5HTP? Ive read it also raises seroronin.
u/MisterYouAreSoDumb
For a normal person, yes. I would suggest our saffron over 5-HTP for daily use. However, in the case of post-MDMA effects, the issue is a reduction in the tryptophan hydroxylase enzyme. The best way to bypass that is to take 5-HTP. So at least for a week or two post MDMA, 5-HTP would be best. Then switching to saffron after for daily use would be better.