Comment · Sun, June 12, 2022
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
Morgan76510 · 1 points
Thank you very much, so quercetin can be included in supplements for example "during" the trip ?
You just have to be careful to start with small doses slightly below the normal dose. Because adding Piperine/grapefruit juice/quercetin/egcg before or during will inhibit the CYP3A4 and CYP2D6 enzymes.
The link I shared looked a bit extreme but I think it's mostly as a precautionary measure in case one is looking to increase doses without considering its parameters.
u/MisterYouAreSoDumb
I mean, I would avoid it out of an abundance of caution. It's probably not a massive risk, but better safe than sorry.