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MDMA Supplementation
Replying to Morgan76510 · Hello, I also came across the lion's mane mushrooms (Hericium erinaceus) and apparently it would have benefits for neuronal protection so anti-neurotoxic it might be good to add th…
Lion's mane is a great mushroom for before and after. I am not sure how it would affect during, though.
MDMA Supplementation
Replying to xezrsps · I've got mdma induced neurotoxicity and possibly some kind of brain damage related to it are there any supplements that help repair the damage caused by this drug
I would focus on things that increase BDNF, NGF, CNTF, and GDNF. This is what I would suggest. * Andrographis * 4'DMA-7,8-DHF * Polygala * Lion's Mane * Poria Then I would add in some everyday staples that you are likely deficient in, or will correct deficiencies. * Micromag * D3…
MDMA Supplementation
Replying to stressedIBguy · Yo grape seed extract reduces estrogen by 80%, you can't just include it here without mentioning that
An acute dose of grapeseed extract will not reduce estrogen by 80%...
MDMA Supplementation
Replying to Morgan76510 · Thank you very much, so quercetin can be included in supplements for example "during" the trip ? You just have to be careful to start with small doses slightly below the normal do…
I mean, I would avoid it out of an abundance of caution. It's probably not a massive risk, but better safe than sorry.
MDMA Supplementation
Replying to Morgan76510 · I just realised that piperine is an MAOI https://nootropicsexpert.com/piperine/ so it could be potentially dangerous to include it with MDMA? Or like Valerian or Passionflower it's…
It will be mild and reversible, like valerian and passionflower.
MDMA Supplementation
Replying to Morgan76510 · One last thing concerning the side effects of MDMA would also be vasoconstriction, in its cases than its self with psychedelics in general it may be preferable to use supplements l…
Yes, those would be good to help with the vasoconstriction.
MDMA Supplementation
Replying to Morgan76510 · Other questions about Quercetin [https://www-worldsbest-rehab.translate.goog/quercetin-and-mdma/?\_x\_tr\_sl=en&\_x\_tr\_tl=fr&\_x\_tr\_hl=fr&\_x\_tr\_pto=sc](https://www-worldsbe…
Inhibiting CYP3A4 and CYP2D6 will both increase MDMA serum levels. This is why you have to be careful, as it might make the effects too strong. Inhibiting the metabolism is good to prevent the toxic metabolites. You just need to keep your doses reasonable. Regular ALA sucks. Na-R…
MDMA Supplementation
Replying to lugaresxcomunes · Hello! Thank you for this! Would Saffron be a good option instead of 5HTP? Ive read it also raises seroronin.
For a normal person, yes. I would suggest our saffron over 5-HTP for daily use. However, in the case of post-MDMA effects, the issue is a reduction in the tryptophan hydroxylase enzyme. The best way to bypass that is to take 5-HTP. So at least for a week or two post MDMA, 5-HTP w…
MDMA Supplementation
Replying to ultimate-sphere · How long should one wait between rolls?
3 months, if you want to keep tolerance at bay.
MDMA Supplementation
Replying to Morgan76510 · I understand, but if we don't have electrolytes, taking highly mineralized or carbonated water may be better than taking plain water. Even though I told you about photosynthesis yo…
Yeah, mineral water would be better than plain water. However, for most people taking either an electrolyte capsule or a dissolving tablet/packet for their water will be easier.
MDMA Supplementation
Replying to Morgan76510 · As far as electrolytes are concerned are you sure that eating well before is left 2 hours for digestion is not a more advisable solution in the sense that we are mainly HETEROTROPH…
The electrolytes are for the water intake, as MDMA can throw your electrolyte balance off and cause a bunch of issues. Plus, people can overheat on MDMA, so they tend to either drink not enough water, which is bad, or too much water, which is also bad. Taking electrolytes with yo…
Ketamine induced neurotoxicity
Replying to SelfAugmenting · Any way to reverse this damage?
Actual ketamine-induced neurotoxicity is from neuronal cell death, so recovering from that is difficult. I would say things that increase/mimic NGF and BDNF would be the best bet. That would be 7,8-dihydroxyflavone, lion's mane, polygala, etc.
MDMA Supplementation
Replying to bob2804 · Yes I don’t take it couple days before and during because this reduces the MDMA roll. However it seems to work really well for my friend and I’m going to roll in 2 weeks and used N…
Let me know how it goes!
MDMA Supplementation
Replying to IncreasinglyTrippy · Does this much Mg glycinate really not cause GI issues? What about your MicroMag? Or stick to the glycinate for this purpose anyway?
I use our Micromag almost exclusively these days. It's just way better for me than any other form.
MDMA Supplementation
Replying to bob2804 · What is the reason it works for a pretty large group then? I know it’s not scientifically proven that it does help but there is a couple studies including rats that shows it protec…
Glutathione is your body's main natural antioxidant. It's a great thing to increase. However, there is just an acute thing with MDMA conjugation that we don't fully understand yet. I think it is fine before and after rolling, but not during. I personally just take reduced glutath…
MDMA Supplementation
Replying to bob2804 · What about NAC?
I wouldn't, as there is some weird glutathione conjugation happening that we don't fully understand yet. https://www.sciencedirect.com/science/article/abs/pii/S0006899303033195
MDMA Supplementation
Replying to Deep_connect · do you have any thoughts on what supplements to add or avoid for reducing very bad headaches as come down starts? I experience it every time and is making me doubt if \`I should ke…
Hmmm, headaches in that scenario are likely from 5-HT2B activation. https://opus4.kobv.de/opus4-fau/files/11219/Segelcke_putative.pdf Preventing that might be difficult. I know some people have luck using CoQ10 to lower headaches, but I am not sure it would work in this exact con…
MDMA Supplementation
Replying to veilpasal · Hey OP! Great and informative post and i appreciate you giving it out there for us. I just wanna ask if you only supplement as u are going to take mdma or you take supplements ahea…
It's good to take the magnesium, CoQ10, and vitamin C every day leading up to it. Magnesium takes time to build up, and both CoQ10 and vitamin C are good daily.
MDMA Supplementation
Replying to Hot_Pop719 · If i got some 200mg webers naturals magnesium bisglycinate, how much should i take ? Normally i take 2x200mg/day when i trip, is it enough ?
That seems to be poor quality magnesium, based on what I am seeing online. They mix magnesium glycinate and cheaper magnesium oxide together. I would get a real fully chelated magnesium glycinate instead.
MDMA Supplementation
Replying to IncreasinglyTrippy · Amazing guide. I love that you’re answering questions 9 years later still. I’m curious if you’d make any updates or additions to the guide after all this time?
I have not made any official updates, no. I'd have to really sit down and think about it. There are certainly things I would change with the knowledge I have now, but it would take some brainstorming to settle on a regimen.
Kratom boasts antipsychotic activity through 5-HT2A antagonism & D2 inhibition
Replying to AlkaliActivated · The science on kratom is evolving rapidly. It was only a couple years ago they discovered speciofoline might play a role in why some kratom samples/batches have different effects t…
https://patents.google.com/patent/US3324111A/en I mean, ol' Beckett here patented this in 1963! The Vietnam war was going on, and this dude was already patenting speciofoline extracted from kratom!
MDMA Supplementation
Replying to poolwater99 · genuine question, im a starter. when it says ‘right before’, am i like, taking all of them all at once? also, are all of these supposed to be taken together? thanks.
Right before is usually 15-30min before. You can take them all together.
MDMA Supplementation
Replying to calvexy · I have purchased ALA and Vitamin C for my next roll!! But I was wondering which suppliments you thinj it is that give you that long afterglow you speak of? Or is it like a mix of a…
I think it is just a mixture of the aftereffects of MDMA paired with the 5-HTP helping to keep serotonin levels higher. That crash from MDMA is partly due to damage and down-regulation, but a big part of it is the reduction in serotonin over the 30 days or so after. It does this…
MDMA Supplementation
Replying to Beginning-Wind-371 · This is a great guide, thanks for sharing! "I take Tums 30min prior to MDMA to lower the acidity and increase absorption." It is known that Tums neutralize the acid in the esopha…
Tums reduces the acids that reach the duodenum, which helps improve absorption. https://www.ncbi.nlm.nih.gov/books/NBK526049/ >The antacids reduce the acid reaching the duodenum by neutralizing the acid present in the stomach.
MDMA Supplementation
Replying to eddysass · Yup I'm reading the nutrition and it says per serving "100mg of R-ALA from 125mg sodium R-alpha lipoate" (I assume the extra 25mg comes from the sodium). So looks like it's stored …
Yeah, that is the sodium salt, so it is stable.