Comment · Thu, December 20, 2012
MDMA Neurotoxicity Part 1 Metabolites)
Original post in this thread
MisterYouAreSoDumb · 129 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
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First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
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MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
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What they were answering
Monkey_in_a_Barrel · 1 points
one thing, what are the doses for each of the things you mentioned? Just wondering how much of each supplement I should take.
And on a different note, does this affect the time you should wait in between doses? I'm currently leaving at least 2 months in between rolls and aiming to do 3 months, would this regimen make it so I could roll more often?
u/MisterYouAreSoDumb
There is no replacement for time off. Down-regulation of your receptors is going to happen no matter what. It's reversible, but still a factor. I would suggest staying safe and sticking to your curent dosing schedule. If you occasionally want to only wait a month, that should not be a problem. Just don't make it a habit.
-Fully chelated magnesium glycinate. Doctor's Best brand is good. Most brands are shit. (Dose 400mg before and during)
-Alpha lipoic acid. You can either get racemic ALA, which is still good. Or you can get fully stabilized R-ALA. Swansons has one that is Na-R-ALA. That is the bonded sodium salt of the dextrorotory isomer of ALA. It reaches 8-10 times the serum levels of normal ALA. It's much better for you. (Dose 100mg before and during. Every hour of roll ideally. every 1.5 if you are using Na-R-ALA.)
-Quercetin supplement. I've used both the GNC brand and Swanson brand. (dose 500mg before and during)
-EGCG (Green tea extract). I use NOW brand 400mg. (Dose before and during)
-Grape seed extract. Just get one high in polyphenols. (Dose 100mg before and after)
-5-HTP. Doctor's best is a good brand for this too. (Dose 100mg with EGCG before bed, then for the next few days. Always take with EGCG.)
-Emergen-C. I get the packets so they fit into my back pocket for easy mixing no matter where you are. (Dose an hour before drop and during)
-Grapefruit juice. Not from concentrate. (Dose an hour before drop and during)
-Tums. (Dose 30min before drop to lower stomach acidity for better absorption of MDMA)
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Optional:
-Inositol. Shown to decrease tolerance buildup. I use NOW brand. (Dose before and after)
-Acetyl-L-Carnitine. Synergistic with ALA and scavenges oxidative substances. Again, I use Doctor's Best.
-Piracetam. I use it the week after MDMA use. 1,600mg 2-3 times per day. You can find bulk powder for super cheap online. If you want to spend more money, Noopept is much stronger
There are other more obscure and expensive things, but the above will work wonderfully.