Comment · Wed, August 28, 2013
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
_______________________________________________________
Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
ADrugUser · 1 points
I was reading rollsafe.org to see what was written and came across this: "Removed Grapefruit juice as a suggestion due to a University Professor's comment that although the MDMA to MDA conversion will be slower, the MDA breakdown may also be slowed, which could lead to potential cardiovascular or liver problems. However he noted that if anyone has sources that they are extremely confident on regarding this it could be re-suggested."
I was just wondering what your opinion on it is.
u/MisterYouAreSoDumb
I've already commented on this a few times. However, I comment too much to be able to go back and find them.
You most definitely want to stop ALL metabolism. Saying that you should take that step out because it slows metabolism is retarded. Yes it will lead to a larger AUC. It will not lead to higher peak plasma levels, but merely shift the curve outward. The only way to increase peak plasma concentrations is to speed up absorption(i.e. Tums).
MDMA's metabolites are the cause of serotonin system neurotoxicity. Saying that we should allow those toxic metabolites to be created because we are afraid of higher plasma concentrations is just plain dumb. Soooo dumb... THAT'S WHAT WE WANT! We want high MDMA plasma concentrations, but low or nonexistent metabolite concentrations. Then we increase our urinary acidity at the end of the roll, which will allow you to pee out the unchanged MDMA before it can become the damaging substances.
Don't take grapefruit juice then take 250mg of MDMA. Take a normal dose, and be sure to increase urinary acidity to help pee it out. This professor is missing the entire point of my supplementation plan, and pretty much the entire point of taking MDMA in the first place. We want high peak plasma concentrations and to shift the curve outwards. That gives us the strongest effects for the longest time. That is the purpose of taking the drug...