Comment · Sun, June 12, 2022
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
Morgan76510 · 2 points
One last thing concerning the side effects of MDMA would also be vasoconstriction, in its cases than its self with psychedelics in general it may be preferable to use supplements like L-Citrulline and L-arginine alpha-ketoglutarate (AAKG) 3 grams each for example to increase vasodilatation before or during the trip?
u/MisterYouAreSoDumb
Yes, those would be good to help with the vasoconstriction.