Comment · Wed, November 17, 2021
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
Beginning-Wind-371 · 1 points
This is a great guide, thanks for sharing!
"I take Tums 30min prior to MDMA to lower the acidity and increase absorption."
It is known that Tums neutralize the acid in the esophagus, which has no effect on absorption of Adderall or Dexedrine. Adderall and Dexedrine are absorbed in the duodenum (which has a baseline pH of 6-7).
Is MDMA absorbed in the esophagus?
u/MisterYouAreSoDumb
Tums reduces the acids that reach the duodenum, which helps improve absorption.
https://www.ncbi.nlm.nih.gov/books/NBK526049/
The antacids reduce the acid reaching the duodenum by neutralizing the acid present in the stomach.