Comment · Sat, November 20, 2021
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
calvexy · 1 points
I have purchased ALA and Vitamin C for my next roll!! But I was wondering which suppliments you thinj it is that give you that long afterglow you speak of? Or is it like a mix of all of them
u/MisterYouAreSoDumb
I think it is just a mixture of the aftereffects of MDMA paired with the 5-HTP helping to keep serotonin levels higher. That crash from MDMA is partly due to damage and down-regulation, but a big part of it is the reduction in serotonin over the 30 days or so after. It does this by lowing tryptophan hydroxylase, which slows production of 5-HTP. Taking 5-HTP for the couple weeks afterward keeps your levels higher, which plays into the afterglow.