Public record · 2012–2026
Everything u/MisterYouAreSoDumb posted, with the thread around it.
A searchable archive of the public Reddit posts and comments. Each item keeps the parent thread title, the original post, who they were answering, the subreddit, and the era it belongs to.
- Posts
- 80
- Comments
- 27,933
- Items
- 28,013
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Best of
The long, cited, mechanism-level replies — not the highest score, the highest density.
Start here · Comment · r/Drugs · Nov 8, 2012
Research Suggests no Neurotoxicity in MDMA
The MDMA body-temperature write-up — papers, mechanisms, and a hard practical rule.
I'm going to copy what I wrote on another thread:
_____________________________________________________
YES! Keep your damn body temperatures down people!
http://www.maps.org/publications/1998_malberg_1.pdf
http://www.springerlink.com/content/5v50nu221g91km35/
http://www.ncbi.nlm.nih.gov/pubmed/21924843
http://jpet.aspetjournals.org/content/270/2/752.short
http://www.maps.org/publications/1998_scheffel_1.pdf
http://journals.lww.com/neuroreport/Abstract/1999/11260/_alpha__Lipoic_acid_prevents.39.aspx
Very simply, MDMA induced neurotoxicity arises from oxidation of various substances in the brain. There is great debate of which substances are to blame. One theory is that a hepatic metabolite of MDMA, being uptaked into the serotonin axon, gets oxidized into damaging hydroxyl radicals. Another theory is that dopamine is the substance to blame for the oxidation. Another theory is that MDMA itself is reuptaked into the axon, being broken down by MAO-B. More likely is that it is a combination of substances being oxidized into harmful hydroxyl radicals. What is the common denominator for all evidence to MDMA's neurotoxicity? BODY TEMPERATURE! When your body temperature rises, you body's natural process for preventing oxidative stress (antioxidants) becomes less efficient. That lowering of efficiency is exponential. The higher your body temperature gets, the faster reactiv
Post · r/DrugNerds · Dec 29, 2012
MDMA Supplementation
Long-form MDMA supplementation notes from the DrugNerds years.
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this
Post · r/Nootropics · Jan 17, 2013
Allometric Scaling of Doses Between Species
Allometric dose scaling between species — still the cleanest explainer in the archive.
I am making this post because I constantly see people making comments that certain substances were given in much higher doses to animals than would be normally ingested by humans. Sometimes that is the case, due to a study's goal of ensuring that certain toxicities can be observed. However, the dosages are NEVER directly related to humans. You cannot take a study that gave 100mg/kg of a substance to rats, then quote
Comment · r/NootropicsDepot · Jun 6, 2026
Concerns about Cistanche Supercritical Extract & Steroidogenesis: Does Acteoside/Verbascoside actually drop Testosterone? (Looking at this 2015 study)
Acteoside/echinacoside as large polar glycosides: why absorption is the whole argument.
No, and most people are missing a massive fundamental point in the bioactives. Acteoside and echinacoside are both large, polar, heavily glycosylated molecules (~624 Da and ~786 Da respectively) with multiple sugar units. They are glycosides that are too large to absorb into the body intact, just like most glycosides found in nature. Acteoside's Caco-2 intestinal absorption is measured at only 0.46–0.70% as an intact
Comment · r/NootropicsDepot · Jul 2, 2020
Immune Defense & positive blood test results
Tongkat ali beyond testosterone — leptin, immune signaling, and a full chain of reasoning.
That's an interesting question. So buckle up, as I imagine this is going to be a long one. So many people know that tongkat ali increases testosterone. However, that is only part of the story. The other big part of the story is leptin. So leptin is a hormone in the body that control hunger and body fat. Obese people actually have a decreased sensitivity to leptin. Tongkat ali decreases leptin levels while increasing
Read by era
Full timeline2012–2014
r/Nootropics years
Long-form replies in r/Nootropics, r/DrugNerds, and r/Drugs. Early vendor work (Ceretropic) and peptide threads such as P21, Semax, and Selank start here.
6,509 items in archive
2015–2017
Ceretropic era
Heavy posting in r/Ceretropic and r/Nootropics. Research peptides, racetams, and the first Nootropics Depot community posts. Ceretropic later stopped US sales.
6,448 items in archive
2018–2022
Nootropics Depot
Almost all activity moves to r/NootropicsDepot under the ND Owner flair. Product launches, COAs, botanicals, and customer support dominate the record.
11,179 items in archive
2023–2024
Enforcement & plea
Public DOJ record: Centera Bioscience d/b/a Nootropics Depot and CEO Paul Eftang (this username) pleaded guilty to introducing misbranded drugs; sentencing in Feb 2024 included probation and forfeiture. The 2024 store relaunch sits in this window.
2,491 items in archive
2025–2026
Botanicals & Q&A
Ongoing r/NootropicsDepot Q&A after the relaunch. Fewer racetam and peptide threads than the 2010s; more standardized botanicals, Cistamax, Eurycomax, and store operations.
1,386 items in archive