MDMA Supplementation

Comment · Sun, December 30, 2012 · 3 pts

Did you lose the "fucked up" feelings? Meaning the light sensitivity, body buzz, urinary retention, jaw clenching, etc.

Comment · Mon, December 31, 2012 · 2 pts

After doing some reading, cimetidine may work. However, it also inhibits CYP2D6. This is definitely going to increase serum levels, so dosage should be lowered. I'd say experiment with an 80mg dose the first time, just t

Comment · Mon, December 31, 2012 · 5 pts

Dextroamphetamine every so often. Kratom every week or two. Marijuana on occasion with friends. Lots of different nootropics. I take Xanax sometimes, usually just for long 9-15 hour plane rides. Salvia a number of differ

Comment · Mon, December 31, 2012 · 1 pts

What type of magnesium did you get?

Comment · Mon, December 31, 2012 · 4 pts

That usually means that you are deficient in choline. Try a choline precursor like soy lecithin, CDP choline, or Alpha GPC, and see how that works.

Comment · Mon, December 31, 2012 · 1 pts

I have taken lots of racetams regularly for over a year. If you are wondering how long it took me to notice effects, immediately. Piracetam is fairly subtle, and will build over time. Stronger racetams will be noticed ve

Comment · Mon, December 31, 2012 · 1 pts

I guarantee that nootropics can help. If not piracetam, there are others that people respond to. Those that do not respond to piracetam seem to respond to aniracetam. As far as the choline thing goes, it varies so much

Comment · Mon, December 31, 2012 · 1 pts

No problem. Glad to help!

Comment · Mon, December 31, 2012 · 2 pts

I understand your concern, but I would highly suggest it. Excitotoxicity leads to tolerance and things like jaw clenching. If bad enough, it can also cause neuronal death. Magnesium glycinate never causes GI tract irrita

Comment · Mon, December 31, 2012 · 1 pts

Do you mean a single attack dose brought back the magic permanently, or do you take one each time you dose MDMA?

Comment · Mon, December 31, 2012 · 14 pts

>DO NOT USE 5-HTP A FEW HOURS BEFORE OR AFTER USING MDMA. That is correct. 5-HTP should only be used once your roll is completely over. >Natural-based Vitamin C is far superior to ascorbic acid. That is also correct.

Comment · Wed, January 30, 2013 · 3 pts

5-HTP will be to restore your serotonin stores after they are depleted. How much you need this is going to depend on the dose you took. Some people need it or they are depressed for a week. Some people don't. Fish oil i

Comment · Thu, January 31, 2013 · 2 pts

I never have any problems with taking pills, nor do I have any issue with appetite or ingesting food/drink while on MDMA. Who would be skeptical about it? If they are already willing to take MDMA, it's not too hard to e

Comment · Thu, January 31, 2013 · 5 pts

Just tell them exactly what they are for, then let them decide if they want to take them or not. If they refuse, and see you perfectly fine the next day while they fell like shit, then next time they might listen.

Comment · Fri, March 8, 2013 · 2 pts

L-Tyrosine and DLPA are precursors to dopamine and norepiniephrine. DLPA being the step before L-tyrosine. Eventually they become L-DOPA, then dopamine. They can actually lower serotonin, due to L-DOPA and 5-HTP competi

Comment · Fri, March 8, 2013 · 2 pts

Dopamine is quick to restore, so you don't have to worry too much about it. If you are only taking 5-HTP for a week or less, then you should be fine. If you take it longer, add some DLPA in.

Comment · Sat, March 9, 2013 · 1 pts

Awesome! Keep me updated.

Comment · Mon, March 11, 2013 · 1 pts

Glad to hear it!

Comment · Tue, March 12, 2013 · 2 pts

Natural sources are always good. However, they usually won't raise your levels the same amount as a specific supplement. The grapefruit juice definitely increases the roll. However, 100mg is perfectly fine. You don't ne

Comment · Tue, March 12, 2013 · 3 pts

With all the acidity from the GFJ and emergen C, your MDMA not absorb very quickly. I take 2-3 Tums about 30min before my first dose. This will make the roll hit much faster and harder. Then I keep drinking acidic drinks

Comment · Wed, March 13, 2013 · 2 pts

No, I have not rolled since before Christmas. My next experience is going to be 6-APB. I have some ready for testing, when the time is right. Have you had any more MDMA experiences?

Comment · Wed, March 13, 2013 · 1 pts

It was either the racetams or the quercetin. The GFJ does not have any MAO-A inhibition, so it's not the cause. Plus GFJ is widely known to potentiate MDMA. Quercetin is not used by many people, but neither are racetams.

Comment · Wed, March 13, 2013 · 1 pts

The mechanism for GFJ inhibition of CYP3A4 is not due to quercetin, as the levels are low. The main cause of GFJ induced inhibition is a furanocoumarin called 6',7'-dihydroxybergamottin, where it actually degrades the CY

Comment · Wed, March 20, 2013 · 2 pts

>The study you referred to contains this illustration which seems to imply that CYP1A2 and CYP2D6 play a bigger role Wow, that's an oversight on their part. They have the figure backwards!! The primary route of metaboli

Comment · Sat, March 23, 2013 · 2 pts

Sure, it plays a role. However, there is not reason to alter the dosage of your supplements. Calculating the differences would be too complicated.

Comment · Sun, March 31, 2013 · 1 pts

Unfortunately, piperine is a CYP2D6 activator. That would lead to more O-demethylation.

Comment · Mon, April 1, 2013 · 1 pts

You know I thought I had one, but I cannot seem to find it now. After doing some more searching I think it has very little CYP2D6 activity. >I was under the impression that the O-demethylation route was safer than N-dem

Comment · Thu, April 4, 2013 · 2 pts

It would do nothing. MDA is not metabolized by CYP3A4. You could try taking a CYP2D6 inhibitor. Since you are already taking MDA, there would be no risk. You might have to lower your dosage, though. Fluoxetine is a stron

Comment · Thu, April 4, 2013 · 2 pts

After the massive dump of 5-HT that MDMA induces, your stores will be so low as it is. Taking both Prozac and 5-HTP should not be an issue, so long as you only take one Prozac dose. Don't keep taking Prozac the following

Comment · Fri, April 5, 2013 · 1 pts

I tried a little experiment with some black pepper. I took 20 or so whole black pepper kernels with my kratom to see how well the CYP3A4 inhibition worked. I also took my grapefruit juice like I normally do. Holy hell di

Comment · Tue, April 9, 2013 · 1 pts

I use that one as well. It's a great liver protector.

Comment · Tue, April 9, 2013 · 1 pts

The N-methyl glutathione/NAC conjugates of MDMA are not found in the brain after dosing. However, they are found in the liver, and cause damage there. The glutathione conjugate of HHA is found in the brain after MDMA dos

Comment · Tue, April 9, 2013 · 1 pts

I am not 100% certain either way. It has the possibility of increasing the toxic metabolites, but it also has the possibility of negating them. I do not think it is a necessary supplement unless you are taking another su

Comment · Wed, April 10, 2013 · 1 pts

Ohh, then I would stay on it. If you are seeing results, keep using it.

Comment · Wed, April 10, 2013 · 1 pts

NMDA receptor antagonists are the best way. Memantine and DXM have both been shown to slow or reverse tolerance. You can also take piracetam with your MDMA to bring back the magic.

Comment · Wed, April 10, 2013 · 1 pts

I have not seen it used in that regard, however it might work.

Comment · Fri, April 12, 2013 · 2 pts

No, not really. Some people get mild depression due to the serotonin stores being depleted. For them the EGCG and 5-HTP can help get things back to normal quicker. If you are taking reasonable doses you should be fine wi

Comment · Tue, May 14, 2013 · 1 pts

You'll probably be fine. The damage from low doses of pure MDMA will most likely be negligible. It's when you start getting to higher doses, elevating your body temperature, or mixing in amphetamine that damage gets to b

Comment · Tue, May 14, 2013 · 2 pts

I err on the side of caution. At the very least, get ALA, magnesium, EGCG, and vitamin C.