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Comment · Mon, December 31, 2012

MDMA Supplementation

Original post in this thread

MisterYouAreSoDumb · 205 points

Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.

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Essential Supplements:

* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…

What they were answering

euphoria_enthusiast · 2 points

Thanks so much, per usual incredibly helpful. Just out of curiosity, what other drugs do you do and with what frequency? Thanks!

u/MisterYouAreSoDumb

Dextroamphetamine every so often. Kratom every week or two. Marijuana on occasion with friends. Lots of different nootropics. I take Xanax sometimes, usually just for long 9-15 hour plane rides. Salvia a number of different occasions, but haven't for a while. I've tried various other opiates/opioids. I've tried coke, but did not like it. NOS a few times, but not regularly. I am going to be trying psilocybin for the first time soon. I am looking forward to it! And I am a craft beer guy, as well as home-brewer, so I drink a lot of beer. So it's mostly nootropics and kratom for me, with the occasional MDMA, D-amphetamine, and weed.

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