Comment · Mon, December 31, 2012
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
_______________________________________________________
Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
slyman928 · 1 points
hmm maybe i'll just take a tums or 2 30 minutes before and with. i don't want rebound acidity right when i start getting the mdma. it seemed to be noticeably stronger last time.
cimetidine inhibits CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. it's interesting though, i was just checking what enzymes are used for MDMA and it says "Several cases have been reported of death in individuals who ingested MDMA while taking ritonavir (Norvir), which inhibits multiple CYP450 enzymes". wikipedia only lists 1A2, 2D6 and 3A4 inhibition for ritonavir.
o and also, i make a shake with this and a banana a few times a week http://isagenix.com/us/en/isaleanshake.dhtml
it contains a few of the things you mentioned. what do you think of drinking it before taking some MDMA? there's an ingredients list at the bottom, i have the chocolate one.
u/MisterYouAreSoDumb
After doing some reading, cimetidine may work. However, it also inhibits CYP2D6. This is definitely going to increase serum levels, so dosage should be lowered. I'd say experiment with an 80mg dose the first time, just to be safe. Also, if it inhibits CYP2D6 more than CYP3A4, then it could lead to more metabolism to MDA than grapefruit juice. However, if it dies inhibit both well, it would work even better, because it would also prevent N-methylated metabolites as well. I'll have to do some more research.
That drink actually looks pretty good. You'll still need to have alpha lipoic acid. I would also recommend adding some more magnesium. The mag citrate in your drink is only about 120mg.