Comment · Tue, March 12, 2013
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
tomhugyous · 1 points
Hi thanks for this, just a few questions:
* Do natural magnesium sources such as bananas/nuts have the correct type of magnesium (glycinate) and are these better or worse than pill-form supplements?
* Does the grapefruit juice noticeably alter one's roll? Someone below mentioned lowering dosage, but i'm wondering if the juice would affect it enough to make this a requirement (standard dose for me is around 100mg).
* Finally, are there any natural sources of alpha-lipoic acid? That stuff is expensive!!
Thanks again.
Edit: Found this link regarding the first point - 'It is also found in red meat, organ meats (such as liver), and yeast, particularly brewer's yeast.' So essentially if I eat steak and drink ale all week would this help? It certainly sounds like a fun few meals! Actually on this point, what would you recommend diet-wise in the week leading up - lots of fish?
u/MisterYouAreSoDumb
Natural sources are always good. However, they usually won't raise your levels the same amount as a specific supplement.
The grapefruit juice definitely increases the roll. However, 100mg is perfectly fine. You don't need to lower your dose.
Yes, you can get ALA from natural sources. However, like magnesium, your plasma levels will not be anywhere near the same as supplementation. A healthy diet is always a good idea, though.