Comment · Tue, May 14, 2013
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
jak34 · 1 points
Here's my question, I've seen all these posts about MDMA neurotoxicity and how the supplements are essential and how you need to put X amount of time between rolls, but really how necessary is this?
Let's say I measure out a dose of 160mg of a very pure MDMA crystal on a scale with a tolerance of 0.005 (5mg), put that in a capsule, and roll tonight. Am I going to be depressed for the rest of my life, do significant damage to my serotonergic system, have significant memory loss, or even perhaps experience severe depression through the next week if I do not take these supplements?
How necessary are these supplements? Or if I simply wait a month to take MDMA again will nature take its course and will I be perfectly fine?
I understand that there is a lot of varying research and misinformation out there about this particular chemical, but it just seems bizarre that one could take LSD every week without seemingly significant consequences or even go through multiple DMT sessions in a single day without any noticeable negative consequences while MDMA on the other hand is made out to seem like I'm ingesting specialized Cyanide for my brain.
u/MisterYouAreSoDumb
You'll probably be fine. The damage from low doses of pure MDMA will most likely be negligible. It's when you start getting to higher doses, elevating your body temperature, or mixing in amphetamine that damage gets to be a problem. However, if you know how to mitigate even a little damage and enhance your experience, why not?
LSD and DMT are not neurotoxic, so that is why they don't cause damage. MDMA is neurotoxic.