MDMA Supplementation

Comment · Mon, December 31, 2012 · 2 pts

I understand your concern, but I would highly suggest it. Excitotoxicity leads to tolerance and things like jaw clenching. If bad enough, it can also cause neuronal death. Magnesium glycinate never causes GI tract irrita

Comment · Mon, December 31, 2012 · 1 pts

Do you mean a single attack dose brought back the magic permanently, or do you take one each time you dose MDMA?

Comment · Mon, December 31, 2012 · 14 pts

>DO NOT USE 5-HTP A FEW HOURS BEFORE OR AFTER USING MDMA. That is correct. 5-HTP should only be used once your roll is completely over. >Natural-based Vitamin C is far superior to ascorbic acid. That is also correct.

Comment · Wed, January 30, 2013 · 3 pts

5-HTP will be to restore your serotonin stores after they are depleted. How much you need this is going to depend on the dose you took. Some people need it or they are depressed for a week. Some people don't. Fish oil i

Comment · Thu, January 31, 2013 · 2 pts

I never have any problems with taking pills, nor do I have any issue with appetite or ingesting food/drink while on MDMA. Who would be skeptical about it? If they are already willing to take MDMA, it's not too hard to e

Comment · Thu, January 31, 2013 · 5 pts

Just tell them exactly what they are for, then let them decide if they want to take them or not. If they refuse, and see you perfectly fine the next day while they fell like shit, then next time they might listen.

Comment · Fri, March 8, 2013 · 2 pts

L-Tyrosine and DLPA are precursors to dopamine and norepiniephrine. DLPA being the step before L-tyrosine. Eventually they become L-DOPA, then dopamine. They can actually lower serotonin, due to L-DOPA and 5-HTP competi

Comment · Fri, March 8, 2013 · 2 pts

Dopamine is quick to restore, so you don't have to worry too much about it. If you are only taking 5-HTP for a week or less, then you should be fine. If you take it longer, add some DLPA in.

Comment · Sat, March 9, 2013 · 1 pts

Awesome! Keep me updated.

Comment · Mon, March 11, 2013 · 1 pts

Glad to hear it!

Comment · Tue, March 12, 2013 · 2 pts

Natural sources are always good. However, they usually won't raise your levels the same amount as a specific supplement. The grapefruit juice definitely increases the roll. However, 100mg is perfectly fine. You don't ne

Comment · Tue, March 12, 2013 · 3 pts

With all the acidity from the GFJ and emergen C, your MDMA not absorb very quickly. I take 2-3 Tums about 30min before my first dose. This will make the roll hit much faster and harder. Then I keep drinking acidic drinks

Comment · Tue, March 12, 2013 · 1 pts

Yes, normal chewable Tums. They will help with the stomach upset too. You can also use ginger to sooth a stomach upset. I like to have a sushi dinner with a bunch of ginger before I roll.

Comment · Wed, March 13, 2013 · 2 pts

No, I have not rolled since before Christmas. My next experience is going to be 6-APB. I have some ready for testing, when the time is right. Have you had any more MDMA experiences?

Comment · Wed, March 13, 2013 · 1 pts

It was either the racetams or the quercetin. The GFJ does not have any MAO-A inhibition, so it's not the cause. Plus GFJ is widely known to potentiate MDMA. Quercetin is not used by many people, but neither are racetams.

Comment · Wed, March 13, 2013 · 1 pts

The mechanism for GFJ inhibition of CYP3A4 is not due to quercetin, as the levels are low. The main cause of GFJ induced inhibition is a furanocoumarin called 6',7'-dihydroxybergamottin, where it actually degrades the CY

Comment · Wed, March 20, 2013 · 2 pts

>The study you referred to contains this illustration which seems to imply that CYP1A2 and CYP2D6 play a bigger role Wow, that's an oversight on their part. They have the figure backwards!! The primary route of metaboli

Comment · Sat, March 23, 2013 · 2 pts

Sure, it plays a role. However, there is not reason to alter the dosage of your supplements. Calculating the differences would be too complicated.

Comment · Sun, March 31, 2013 · 1 pts

Unfortunately, piperine is a CYP2D6 activator. That would lead to more O-demethylation.

Comment · Mon, April 1, 2013 · 1 pts

You know I thought I had one, but I cannot seem to find it now. After doing some more searching I think it has very little CYP2D6 activity. >I was under the impression that the O-demethylation route was safer than N-dem

Comment · Thu, April 4, 2013 · 2 pts

After the massive dump of 5-HT that MDMA induces, your stores will be so low as it is. Taking both Prozac and 5-HTP should not be an issue, so long as you only take one Prozac dose. Don't keep taking Prozac the following

Comment · Fri, April 5, 2013 · 1 pts

I tried a little experiment with some black pepper. I took 20 or so whole black pepper kernels with my kratom to see how well the CYP3A4 inhibition worked. I also took my grapefruit juice like I normally do. Holy hell di

Comment · Tue, April 9, 2013 · 1 pts

I use that one as well. It's a great liver protector.

Comment · Tue, April 9, 2013 · 1 pts

The N-methyl glutathione/NAC conjugates of MDMA are not found in the brain after dosing. However, they are found in the liver, and cause damage there. The glutathione conjugate of HHA is found in the brain after MDMA dos

Comment · Tue, April 9, 2013 · 1 pts

I am not 100% certain either way. It has the possibility of increasing the toxic metabolites, but it also has the possibility of negating them. I do not think it is a necessary supplement unless you are taking another su

Comment · Wed, April 10, 2013 · 1 pts

Ohh, then I would stay on it. If you are seeing results, keep using it.

Comment · Wed, April 10, 2013 · 1 pts

NMDA receptor antagonists are the best way. Memantine and DXM have both been shown to slow or reverse tolerance. You can also take piracetam with your MDMA to bring back the magic.

Comment · Wed, April 10, 2013 · 1 pts

I have not seen it used in that regard, however it might work.

Comment · Fri, April 12, 2013 · 2 pts

No, not really. Some people get mild depression due to the serotonin stores being depleted. For them the EGCG and 5-HTP can help get things back to normal quicker. If you are taking reasonable doses you should be fine wi

Comment · Tue, May 14, 2013 · 1 pts

You'll probably be fine. The damage from low doses of pure MDMA will most likely be negligible. It's when you start getting to higher doses, elevating your body temperature, or mixing in amphetamine that damage gets to b

Comment · Tue, May 14, 2013 · 2 pts

I err on the side of caution. At the very least, get ALA, magnesium, EGCG, and vitamin C.

Comment · Thu, May 30, 2013 · 1 pts

Usually 150mg with a 75mg redose.

Comment · Fri, June 14, 2013 · 7 pts

That has horrible bioabailability, and will make you shit yourself.

Comment · Mon, June 17, 2013 · 1 pts

Awesome! The afterglow is the best part! What magnesium did you use. Certain forms can cause diarrhea. If it was glycinate, then you might need to look into another form like L-threonate.

Comment · Mon, June 17, 2013 · 1 pts

Haha, that's weird! Grapefruit juice doesn't give me the squirts. Everyone is different, though. Maybe you should try black pepper extract instead. That inhibits CYP3A4. http://www.ncbi.nlm.nih.gov/pubmed/12130727

Comment · Fri, June 21, 2013 · 2 pts

Rollsafe made their page off my supplement guide. He does not know the pharmacology of it. He just merely made my guide, along with some other people's guides, into an easier to read format. Whoever that "professor" is d

Comment · Fri, June 21, 2013 · 1 pts

Grape seed oil will not work, as the antioxidants are not really soluble in lipids. You need a solvent extract of the seed, not cold pressed like the oil is.

Comment · Sat, June 22, 2013 · 1 pts

I usually just do oral administration. I have a sushi dinner about 5 hours before, then drop on an empty stomach with some Tums. I've never worked up the gumption to stick it up the rear. I have snorted it before, when I

Comment · Sat, June 22, 2013 · 1 pts

It's not super critical. Usually 1-2 hours before the roll.