Comment · Mon, December 31, 2012
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
drpotatoe · 8 points
I have a few things to add:
1) DO NOT USE 5-HTP A FEW HOURS BEFORE OR AFTER USING MDMA. It can cause serotonin syndrome. Happened to me once. Not fun.
2) Natural-based Vitamin C is far superior to ascorbic acid. Ascorbic acid is much less bio-available than vitamin C derived from fruits. Either get your Vitamin C from real fruit or a natural supplement.
3) Supplementation is good practice, but not necessary if using high-quality MDMA in moderation. Supplementation should still be used as a precaution, just because there is a decent chance the MDMA is not high-quality, and most individuals do not use MDMA in moderation.
The neurotoxic effects of MDMA are overhyped on reddit and the scientific community at large, and the neurotoxicity is much more open to debate than people are willing to talk about from a scientific standpoint. From a behavioral standpoint, I see more of an impact from LSD use than MDMA, and LSD is non-toxic and perfectly safe compared to MDMA supposedly...
u/MisterYouAreSoDumb
DO NOT USE 5-HTP A FEW HOURS BEFORE OR AFTER USING MDMA.
That is correct. 5-HTP should only be used once your roll is completely over.
Natural-based Vitamin C is far superior to ascorbic acid.
That is also correct. However, bringing a little packet of Emergen-C into a club is much easier than a bottle of fresh squeezed orange juice.
Supplementation is good practice, but not necessary if using high-quality MDMA in moderation.
This is where I start to disagree. There is much evidence of cognitive deficits with even single uses of MDMA. I know the mechanisms, and how to prevent it. Why would you not heed that advice and protect yourself as much as you can? Not only that, but it makes your roll better, and you have a 2 week long afterglow. It enhances every part of the experience.
The neurotoxic effects of MDMA are overhyped on reddit
Again, I totally disagree. I have made a bunch of comments and posts now about MDMA. The amount of misinformation that I see is astounding. Many people PM me after my posts saying that they had no idea MDMA was even dangerous. If I can get people realizing the real risks behind what they do, then that is a good thing. I take MDMA myself, so I am not trying to scare people away. I simply want them to realize the risks of taking it.
Read through these links I posted the other day: http://www.reddit.com/r/Drugs/comments/15ix0s/what_are_the_symptoms_of_repeated_mdma_use_in_a/c7mvi4i
There is a lot of evidence for measurable cognitive deficits due to MDMA use.