Comment · Sun, December 30, 2012
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
slyman928 · 1 points
i've read that it's best to take tums with the MDMA because if you take it too early it can cause your stomach to be even more acidic due to your body trying to maintain homeostasis.
also, recently i read this on the wikipedia page for melatonin "Redox cycling may allow other antioxidants (such as vitamin C) to act as pro-oxidants, counterintuitively promoting free radical formation"
i see you briefly mentioned that vitamin c does this in the ALA part.
lastly, how about tagamet/cimetidine for enzyme inhibition? or is gfj better because it's more specific?
u/MisterYouAreSoDumb
30min before works well for the Tums.
Redox cycling shouldn't be an issue due to the other antioxidants able to scavenge any hydrogen peroxide that may be created. There has also not been conclusive evidence that it happens in vivo enough to be detrimental.
I am unaware of cimetidine inhibiting CYP3A4. Also, it has other effects that could cause contraindications. I'd stick to grapefruit juice.