Comment · Thu, June 20, 2013

Are there any effects of MAOI on Kratom alkaloids?

Original post in this thread

[deleted] · 10 points

Dear DrugNerds,
as I read about potential ways to enhance the effects of Kratom and its respective alkaloids, I stumbled upon various mentions of MAOIs (especially the very weak ones found in Grapefruit Juice (Naringenin and Bergamottin)) as possible substances.
Is there any scientific guess wether this could work? Since Mytragnin is indol-based, I don't see a way how a MAOI could affect its metabolism anyhow.
Thanks!

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb

Bergamottin and naringin(not naringenin) inhibit CYP3A4, which is what metabolizes the active substances in kratom. It has nothing to do with the MAOI characteristics. I drink grapefruit juice with my kratom all the time. It definitely increases the potency.

Other MYASD lines in this thread

Related in the archive

Commentr/NootropicsDepotAug 10, 2022Nootropics DepotND Owner

Nootopia's "Omnipept"

Empirical consensus? You mean their constant advertising and shilling?!? They only popped up as a brand last year, and have been heavily advertising things. If anyone here is even remotely considering buying a product th

34AshwagandhaRacetamsKratom

Commentr/DrugNerdsDec 31, 2012r/Nootropics years

MDMA Supplementation

Replying to euphoria_enthusiast · Thanks so much, per usual incredibly helpful. Just out of curiosity, what other drugs do you do and with what frequency? Thanks!

Dextroamphetamine every so often. Kratom every week or two. Marijuana on occasion with friends. Lots of different nootropics. I take Xanax sometimes, usually just for long 9-15 hour plane rides. Salvia a number of differ

5Kratom

Commentr/NootropicsMar 3, 2020Nootropics DepotNatrium Health & Nootropics Depot

black seed oil (1 month update)

Replying to antitetico · As far as I understand, the extract from ND is just a worse value than the oil if it doesn't bug your stomach. Each capsule is labeled 200 mg, but only 5% of that is guaranteed to …

You're comparing our capsules to their bottled oil. That's not like-for-like. You should compare our capsules to their softgels, then compare our powder to their oil. If you take out all the cost of encapsulation, of cou

26Kratom

Commentr/NootropicsFeb 7, 2026Botanicals & Q&ANatrium Health & Nootropics Depot

The story behind the FDA raid of Nootropics Depot

Replying to ProperBeat · Priceplow is pretty biased guys Here's [a more objective description](https://www.justice.gov/usao-nh/pr/arizona-company-and-ceo-sentenced-illegal-distribution-tianeptine-and-othe…

...continued... Now a little backstory here... we did sell tianeptine years prior. I explained it in the podcast, but I will reiterate some here. I went through a bad depression when I was younger, and almost took my li

25TianeptineKratom

Commentr/NootropicsAug 31, 2016Ceretropic eraCeretropic & Nootropics Depot

DEA to place Mitragyna speciosa (Kratom) and its active alkaloids mitragynine and 7-hydroxymitragynine into Schedule I on 30. September 2016.

Replying to silverlinin · Does this affect other countries from importing as well? Like Australia? So this means people won't be able to buy it without a prescription?

If the US puts kratom in schedule 1, most of the world is going to follow suit. This is due to United Nations guidelines that we force everyone to adhere to. This action is going to be very bad for everyone, not just the

25Kratom

Commentr/DrugNerdsMar 15, 2022Nootropics Depot

Kratom boasts antipsychotic activity through 5-HT2A antagonism & D2 inhibition

Replying to AlkaliActivated · The science on kratom is evolving rapidly. It was only a couple years ago they discovered speciofoline might play a role in why some kratom samples/batches have different effects t…

https://patents.google.com/patent/US3324111A/en I mean, ol' Beckett here patented this in 1963! The Vietnam war was going on, and this dude was already patenting speciofoline extracted from kratom!

4Kratom