Comment · Sat, December 29, 2012
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
[deleted] · 1 points
When you say that you should take a certain supplement before the use of MDMA, how long pre-MDMA should you take it? An hour? Half an hour?
I also want to say that this is all great but if you stick to ~80-120mg of MDMA every 2-3 months without pre- or post-loading you'll be more than fine as well.
u/MisterYouAreSoDumb
If I do not specify an exact dosing schedule, then it's not a supplement that is super time sensitive. I try and space my supplements out the few hours before the roll, ending about 1 hour ahead of time. That way your body can absorb them efficiently. Alpha lipoic acid is one that is time sensitive, due to it's short half life. However, if you use Na-R-ALA, then it extends it significantly. Drink grapefruit juice the night before, and all day before your roll. I stop 1 hour ahead of time so that I can take Tums and reduce my stomach acidity to absorb the MDMA. Then I start drinking it again about an hour into my roll. The ones you take during your roll are going to be dependent on when you remember, and when is a good time, given your location.
And as assliquorr said, even single doses of MDMA can cause measurable damage. If you have the knowledge to prevent it, I would suggest it.