MDMA Supplementation

Post · Sat, December 29, 2012 · 205 pts

Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory

Comment · Sat, December 29, 2012 · 7 pts

That is an unproven theory, one which I doubt the validity of. MDMA is not neurotoxic when injected directly in the brain, even when dopamine levels rise and serotonin is depleted. This is pretty conclusive evidence that

Comment · Sat, December 29, 2012 · 2 pts

Yes, amphetamine does not need CYP3A4 inhibition.

Comment · Sat, December 29, 2012 · 2 pts

That is why I say throughout the day, before, and during. Also, the grape seed extract has some CYP3A4 inhibition. I also take quercetin as well.

Comment · Sat, December 29, 2012 · 6 pts

If I do not specify an exact dosing schedule, then it's not a supplement that is super time sensitive. I try and space my supplements out the few hours before the roll, ending about 1 hour ahead of time. That way your bo

Comment · Sat, December 29, 2012 · 1 pts

Most of the forms of magnesium I mentioned will not upset your GI tract. Citrate may, and I have heard anecdotes of taurate as well. Glycinate never upsets my stomach, even at high doses. I really like glycinate.

Comment · Sat, December 29, 2012 · 2 pts

Actually, yes. I have different ones in each pocket. I am overly cautious, though. You don't need all the ones I mentioned. Before and after will always be better than nothing.

Comment · Sat, December 29, 2012 · 1 pts

I'm sure you can bring an Emergen-C packet in your back pocket. If not, the extended release C will be fine. Just make sure you watch your electrolyte intake with your water.

Comment · Sat, December 29, 2012 · 2 pts

What do you think about creatine for increasing ATP synthesis?

Comment · Sat, December 29, 2012 · 1 pts

Have you tried that yourself? Do they have any other interactions?

Comment · Sun, December 30, 2012 · 3 pts

I assume that you "lost the magic?" Out of curiosity, what made your realize it? Did taking MDMA no longer result in any effects?

Comment · Sun, December 30, 2012 · 3 pts

I spoke to Borax about it, and I think I'm going to simplify it a bit before posting there.

Comment · Sun, December 30, 2012 · 2 pts

Personally, I do not life the feeling of MDMA on any of the racetams. It potentiates it, but kills the empathy for me.

Comment · Sun, December 30, 2012 · 1 pts

30min before works well for the Tums. Redox cycling shouldn't be an issue due to the other antioxidants able to scavenge any hydrogen peroxide that may be created. There has also not been conclusive evidence that it hap

Comment · Sun, December 30, 2012 · 1 pts

I always have racetams (oxiracetam, piracetam, noopept) after my roll. The racetams seem to make me irritable at times, and the same holds true while on MDMA. It's interesting you and your friends have the opposite effec

Comment · Sun, December 30, 2012 · 3 pts

Did you still have the side effects, or nothing at all?

Comment · Sun, December 30, 2012 · 2 pts

I was putting it on, but it was late and I could not find enough sources to be thorough. I use it along with my magnesium.

Comment · Sun, December 30, 2012 · 1 pts

It's possible that they would degrade in the acidic juice.

Comment · Sun, December 30, 2012 · 3 pts

Did you lose the "fucked up" feelings? Meaning the light sensitivity, body buzz, urinary retention, jaw clenching, etc.

Comment · Mon, December 31, 2012 · 2 pts

After doing some reading, cimetidine may work. However, it also inhibits CYP2D6. This is definitely going to increase serum levels, so dosage should be lowered. I'd say experiment with an 80mg dose the first time, just t

Comment · Mon, December 31, 2012 · 5 pts

Dextroamphetamine every so often. Kratom every week or two. Marijuana on occasion with friends. Lots of different nootropics. I take Xanax sometimes, usually just for long 9-15 hour plane rides. Salvia a number of differ

Comment · Mon, December 31, 2012 · 1 pts

What type of magnesium did you get?

Comment · Mon, December 31, 2012 · 4 pts

That usually means that you are deficient in choline. Try a choline precursor like soy lecithin, CDP choline, or Alpha GPC, and see how that works.

Comment · Mon, December 31, 2012 · 1 pts

I have taken lots of racetams regularly for over a year. If you are wondering how long it took me to notice effects, immediately. Piracetam is fairly subtle, and will build over time. Stronger racetams will be noticed ve

Comment · Mon, December 31, 2012 · 1 pts

I guarantee that nootropics can help. If not piracetam, there are others that people respond to. Those that do not respond to piracetam seem to respond to aniracetam. As far as the choline thing goes, it varies so much

Comment · Mon, December 31, 2012 · 1 pts

No problem. Glad to help!

Comment · Mon, December 31, 2012 · 2 pts

I understand your concern, but I would highly suggest it. Excitotoxicity leads to tolerance and things like jaw clenching. If bad enough, it can also cause neuronal death. Magnesium glycinate never causes GI tract irrita

Comment · Mon, December 31, 2012 · 1 pts

Do you mean a single attack dose brought back the magic permanently, or do you take one each time you dose MDMA?

Comment · Mon, December 31, 2012 · 14 pts

>DO NOT USE 5-HTP A FEW HOURS BEFORE OR AFTER USING MDMA. That is correct. 5-HTP should only be used once your roll is completely over. >Natural-based Vitamin C is far superior to ascorbic acid. That is also correct.

Comment · Wed, January 30, 2013 · 3 pts

5-HTP will be to restore your serotonin stores after they are depleted. How much you need this is going to depend on the dose you took. Some people need it or they are depressed for a week. Some people don't. Fish oil i

Comment · Thu, January 31, 2013 · 2 pts

I never have any problems with taking pills, nor do I have any issue with appetite or ingesting food/drink while on MDMA. Who would be skeptical about it? If they are already willing to take MDMA, it's not too hard to e

Comment · Thu, January 31, 2013 · 5 pts

Just tell them exactly what they are for, then let them decide if they want to take them or not. If they refuse, and see you perfectly fine the next day while they fell like shit, then next time they might listen.

Comment · Fri, March 8, 2013 · 2 pts

L-Tyrosine and DLPA are precursors to dopamine and norepiniephrine. DLPA being the step before L-tyrosine. Eventually they become L-DOPA, then dopamine. They can actually lower serotonin, due to L-DOPA and 5-HTP competi

Comment · Fri, March 8, 2013 · 2 pts

Dopamine is quick to restore, so you don't have to worry too much about it. If you are only taking 5-HTP for a week or less, then you should be fine. If you take it longer, add some DLPA in.

Comment · Sat, March 9, 2013 · 1 pts

Awesome! Keep me updated.

Comment · Mon, March 11, 2013 · 1 pts

Glad to hear it!

Comment · Tue, March 12, 2013 · 2 pts

Natural sources are always good. However, they usually won't raise your levels the same amount as a specific supplement. The grapefruit juice definitely increases the roll. However, 100mg is perfectly fine. You don't ne

Comment · Tue, March 12, 2013 · 3 pts

With all the acidity from the GFJ and emergen C, your MDMA not absorb very quickly. I take 2-3 Tums about 30min before my first dose. This will make the roll hit much faster and harder. Then I keep drinking acidic drinks

Comment · Tue, March 12, 2013 · 1 pts

Yes, normal chewable Tums. They will help with the stomach upset too. You can also use ginger to sooth a stomach upset. I like to have a sushi dinner with a bunch of ginger before I roll.