Comment · Wed, June 8, 2022 · ND Owner
Interactions checker would be extremely helpful for a lot of us
Original post in this thread
AvgAIbot · 33 points
An interactions checker for ND products would be awesome.
Many of us end up having big stacks; it’d be nice to know if any products didn’t play well with each other.
I know it’s a huge project. An easier step would be to maybe put a warning on the product page for products that have specific bad interactions.
Or am I just misinformed and pretty much any ND products can be taken together without serious issues?
What they were answering
[deleted] · 1 points
[deleted]
u/MisterYouAreSoDumb · ND Owner
The rat model in that study applies to humans, too. This is because NAC can become pro-oxidant in certain scenarios. They also found that NAC's protective effects from ethanol-induced toxicity were not due to increases in glutathione, but were more a direct effect on limiting TNF-α. When taking NAC after drinking alcohol, TNF-α was not limited, and NAC turned pro-oxidant, which made the damage worse. It's because NAC's actions are based on the basal redox balance of the body at time of administration. Before alcohol consumption, the body is in redox balance. After alcohol consumption it interacts with ROS generated by ethanol to generate thiyl radicals, which then impart a pro-oxidant effect. NAC in the presence of H2O2 goes through something called auto-oxidation, which then leads to more hydroxyl radicals. This means that taking NAC after anything that increases ROS will cause more damage. This is why I have moved completely to just taking reduced glutathione daily, and leaving NAC out of my regimen with alcohol. I just take 3 tablets of reduced glutathione every day, then I don't have to time anything. If I drink too much, I just add in our Alcohol Defense after, and sometimes Immune Defense, and I am golden.