Comment · Sat, June 2, 2018 · Natrium Health & Nootropics Depot
Nootropics depot Magnesium glycinate
Original post in this thread
narcissistic889 · 2 points
may or may not be the place for this, but the dose recommendation for mag glycinate powdered form is 1200 mg twice daily with a 14% elemental magnesium content. This seems like a lot, does this seem like too large of a dose?
What they were answering
packagefiend · 1 points
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
That post incorrectly says that all magnesium forms are salts. That's false. Salts are ionic bonds. Magnesium forms, like glycinate and L-threonate, are chelated. Those are coordinate bonds, which are a type of covalent bond; not an ionic bond. Therefore, they are not salts, and do not immediately disassociate in solution. Even if they were just salts, different types of salts certainly do affect how things absorb and react in the body. Take tianeptine sodium vs tianeptine sulfate for example. The pKa affects it a lot, and dictates its ability to solvate at specific pH levels. Even the study linked in a comment on that post says that magnesium oxide is virtually insoluble in water at a neutral pH, while magnesium citrate is very water soluble.
Furthermore, magnesium chelates do not absorb through the ion channels like magnesium salts do. They don't even dissociate in the stomach. They absorb through other transport sites called dipeptide channels. They then get transported across the intestinal membrane intact as chelated magnesium-amino acid pairs. There are more dipeptide channels in the GI tract than their are ion channels. So you can absorb more chelated magnesium than you can ionic magnesium in a given amount of time. On top of that, magnesium is very reactive. So magnesium oxide can form complexes with insoluble compounds in your GI tract, which you then excrete out. So you lose all the magnesium because it formed insoluble complexes with other stuff in your GI tract. That doesn't happen with chelated magnesium. People report diarrhea with magnesium oxide all the time. Why is that? Well, when there are more mineral ions in the GI tract than there are in the surrounding intestinal wall, the osmotic effect tries to equalize the concentration. So that means water flows out of the intestinal walls and into the GI tract, which can then cause bloating and diarrhea. Take a good dose of magnesium sulfate orally and tell me what happens later.
So that post starts with a flawed premise, then makes assertions based on that faulty premise. Not all magnesium forms are salts, nor are all salts even the same. If we only had magnesium salts, then the premise would be closer to reality. However, the fact that chelated forms of magnesium bypass the ion channels, and do not dissociate in the stomach, is a massive reason for why they are improved. You can't compare magnesium citrate or sulfate to something like glycinate or L-threonate, nor can you directly compare citrate to oxide; as the pKa dictates the water solubility at the various pH levels. A salt must solvate to dissociate into ionic magnesium, which then allows it to absorb through the ion channels. However, the pKa of the salt determines where/when it will solvate in the GI tract. The salt of a strong acid is less affected by changes in the pH than is the solubility of a salt of a weak acid, for instance. A chelated metal pair does NOT need to dissociate to absorb in the GI tract, due to the dipeptide channels. So trying to compare it to a salt is comparing two completely different things.