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The story behind the FDA raid of Nootropics Depot
Replying to verifitting · > I plead guilty to a strict liability misdemeanor, and the government did not allege intent, or push for a felony with me. I genuinely thought that there was a legal pathway to se…
Depends on how you calculate it. It cost me around $15M directly, because I had to sell all the company crypto to pay legal fees after we had the crash in 2022. It was around $4.5M in seized and destroyed inventory from the day of the raid, and other batches they missed that we d…
The story behind the FDA raid of Nootropics Depot
Replying to verifitting · MYASD coming in with the receipts
This is why I was so confused when they raided us. We were going so much farther to comply with the regulations than any other vendor in the space. I could have sold way more product had I been doing what every other nootropics vendor was doing, and what multiple still are doing…
The story behind the FDA raid of Nootropics Depot
Replying to AAAUUUUAUAUAUUAUA · Very, very cool, i hope you publish all the data, including the non hits, that would be very exciting. The functionality based studies will be very cool but i think im most excited…
We will publish all the data, including the negative results, as that is useful for understanding what each bioactive is and is not doing.
The story behind the FDA raid of Nootropics Depot
Replying to RarageInTheGarage · Acetaminophen formulations should've been required to include NAC from the start.
I know it is not quite fair, because the amount of people that use each is very different. However, sometimes you have to put things in proper context. It's easy to see a CNN or NPR piece on "gas station heroin" and then demonize anyone that has ever used or sold it, but the real…
The story behind the FDA raid of Nootropics Depot
Replying to RarageInTheGarage · A lot of other tricyclic antidepressants also have opioid affinity, as it turns out. Some friends of mine with neuropathic pain were prescribed certain TCA's for just that reason.
Well the opioid affinities for some of the TCAs are delta and kappa opioid receptors, not mu opioid. Even then, they are low affinities. https://pubmed.ncbi.nlm.nih.gov/19828880/ >At the cloned mu-opioid receptor, TCAs showed low affinity and no significant agonist activity. Thes…
The story behind the FDA raid of Nootropics Depot
Replying to DoctorBoneMarrow · Here in Spain it's approved as an antidepressant!
Yeah, that's true. I meant in the US. We get fucked by our pharma system here. It's about profits first and foremost.
The story behind the FDA raid of Nootropics Depot
Replying to AAAUUUUAUAUAUUAUA · Understandable. Considering you guys came out with cognance im sure you have put some thought into the biotransformation aspect of this. We will be waiting excitedly for the result…
We've already done some molecular docking studies in software, to give us an idea of what they might be. We will be pairing that up with receptor knockout assays in the cell cultures. We will be blocking various receptors in the brain cells, then assessing how that affects each g…
The story behind the FDA raid of Nootropics Depot
Replying to AAAUUUUAUAUAUUAUA · Thats fair enough, but i ment for the in vitro studies, it does not make sense to use a "pro-drug" with a bulky side chain. However, i think most if not practically every study ive…
I am being a bit opaque, because sometimes I have to be for multiple reasons, but rest assured we are taking all this into account in our research. We are absolutely doing cell culture work with individual bioactive compounds themselves, in addition to them grouped together in a…
The story behind the FDA raid of Nootropics Depot
Replying to AAAUUUUAUAUAUUAUA · That would be super cool to get some more data on lions mane bioactives, however, one thing that i had not really thought that much about until recently is that probably a signific…
Well yeah, that happens all the time with the glycosides in plants. Our body usually cleaves off the glycoside groups before they go to work in the body. It's like the difference between baicalin and baicalein. The glycosides make the compound more water soluble, then the body ri…
The story behind the FDA raid of Nootropics Depot
Replying to PIQAS · I hear your skepticism u're picturing a dry talking head documentary that only biohackers would sit through lol but that’s not what I’m talking about. and i understand the stereoty…
LOL, it does sound interesting when you put it that way. A good screenwriter and director would make all the difference for how engaging it would feel.
The story behind the FDA raid of Nootropics Depot
Replying to PIQAS · DEAR GOD, YOU SHOULD SERIOUSLY CONSIDER TURNING THIS INTO A NETFLIX MOVIE OR SHORT-SERIES OR SOMETHING. NOT ONLY IT IS INTERESTING AND SHOWS A LOT ABOUT THE INDUSTRY IN UNTESTED/NO…
I mean, that might sounds interesting to us, but would the average Netflix watcher find it interesting enough?
The story behind the FDA raid of Nootropics Depot
Replying to MrTomen · Thank you for explaining this so clearly. I watched your interview @PricePlow and now this and am grateful. For your work and contribution to this world. For years I've tried to e…
When everything went down with the government, I was instructed by my legal team to say absolutely nothing to anyone about it. That's exactly what we did. We went completely silent on it for two years. This opened the door to conspiracy theories and weird made up theories from pe…
The story behind the FDA raid of Nootropics Depot
Replying to Dihexa_Throwaway · > We are literally working on brain cancer with some of the most respected institutions in the world now. Would you mind sharing more about that?
It's still ongoing, and we have NDAs, so I can't say the exact names of who is involved, but everyone here would know the name if I said it. However, we are studying Erinamax, eriancine A, and other erinacines for their use in brain cancer patients. The initial data is really rea…
The story behind the FDA raid of Nootropics Depot
Replying to DoctorBoneMarrow · Can you share why you think tianeptine is such a good antidepressant (mechanistically speaking) when used correctly? Do you think it might have an interesting synergy with Cognan…
When we first brought it out, the SSRE effects were interesting, as no other antidepressants had that effect. When we learned it had opioid affinities, that wasn't a bad thing at first. Your body has endogenous compounds that bind to the opioid receptors called endorphins, enkeph…
The story behind the FDA raid of Nootropics Depot
Replying to CrystalSplice · You never should have sold it in the first place.
It's easy to say that in retrospect, but nobody knew tianeptine could be abused when we brought it out. We sold tianeptine sodium for less than 3 years. When it was clear what it had become, we stopped selling it. Other vendors sold it much much longer than we did. Nootropic Sour…
The story behind the FDA raid of Nootropics Depot
Replying to RainyVibez · > I realised tianeptine as a whole was toxic Is this in regards to the usage of tianeptine, or is it in regards to the properties of tianeptine? Tianeptine sulfate does seem bene…
Sorry if my phrasing wasn't clear. The tianptine MARKET was toxic, not the compound itself; toxic meaning something I didn't want to be associated with, which is why we stopped selling it in 2017/2018.
The story behind the FDA raid of Nootropics Depot
Replying to Megatron_McLargeHuge · I though it was about Tianeptine. Or was that a different case?
Tianeptine, adrafinil, piracetam, aniracetam, oxiracetam, phenylpiracetam, pramiracetam, etc. You can read my long comment on it above. We had stopped selling tianeptine years prior to the government coming into our facility, but we were selling racetams and adrafinil on the ND s…
The story behind the FDA raid of Nootropics Depot
Replying to drAsparagus · u/MrYouAreSoDumb still around? He was super active here back in those days.
Yep, I am here. Well I am not here here, meaning on /r/Nootropics. Everyone kept spreading lies about me being a moderator here that abuses my powers and removing competitor posts, even though it was the exact opposite of the facts. That's why I made /r/NootropicsDepot instead. P…
The story behind the FDA raid of Nootropics Depot
Replying to Doxylaminee · Yep. The main issue was, if anyone remembers, labeling stated benefits of their products in their listings. White phenibut, it was marketed as helping with anxiety.
That is incorrect. Here is a snapshot of our piracetam in November 2021, the month before we were raided. https://web.archive.org/web/20211222040313/https://nootropicsdepot.com/piracetam/ We did not give effect claims on our labels or on the site. We did not discuss diseases, nor…
The story behind the FDA raid of Nootropics Depot
Replying to Black_Cat_Fujita · ND stopped selling racetams long after this raid. The raid had more to do with labelling than what was being sold. During and after Covid was when his company morphed into a propri…
That's incorrect. It had nothing to do with labeling at all. We did not label these compounds as supplements, didn't make disease claims, and didn't make structure function claims. We called them nootropic compounds, and were very careful about how we labeled them. This is also w…
The story behind the FDA raid of Nootropics Depot
Replying to CrystalSplice · ND was selling tianeptine and andrafanil?!? What the fuck did they call it, and also what the fuck did they expect? Racetams should be left alone by the government in my opinion b…
Read my reply above. We stopped selling tianeptine years before the government came into our facility. NewMind, Powder City, Nootropic Source, and many others continued to sell tianptine LONG after we stopped... some to this very day. We willingly stopped in 2017 and 2018.
The story behind the FDA raid of Nootropics Depot
Replying to ProperBeat · Priceplow is pretty biased guys Here's [a more objective description](https://www.justice.gov/usao-nh/pr/arizona-company-and-ceo-sentenced-illegal-distribution-tianeptine-and-othe…
...continued... Now a little backstory here... we did sell tianeptine years prior. I explained it in the podcast, but I will reiterate some here. I went through a bad depression when I was younger, and almost took my life on a number of occasions. Coming out of that depression is…
The story behind the FDA raid of Nootropics Depot
Replying to ProperBeat · Priceplow is pretty biased guys Here's [a more objective description](https://www.justice.gov/usao-nh/pr/arizona-company-and-ceo-sentenced-illegal-distribution-tianeptine-and-othe…
That is not an objective description... This is a more objective description by the FDA and DOJ: https://www.justice.gov/usao-nh/pr/arizona-company-and-ceo-plead-guilty-distribution-drugs-not-approved-fda-and-will-pay-24 Even that is nowhere near all of it, but the one you posted…
Any good site or app that shows which supplements are actually backed by science?
Replying to Jarwain · I can say that the section under it with "build your stack" is more clear because I can see the part of the next card. That vertical line feels like "oh there's another card" but t…
I'm going to work on making it more clear, because I agree with you. I always questioned whether or not people would know to swipe over on mobile for more.
Any good site or app that shows which supplements are actually backed by science?
Replying to voyager256 · Yeah Examine is great, but I skimmed through the ND links you provided , but everything seems vague and I’d say even sketchy. E.g. It doesn’t seem like any of the scientific board …
You're saying doctor Lindsay Faucette, who is double board certified in family medicine and integrative medicine, didn't "study and graduate medical studies?" Is that what you are saying? Are you also saying that someone with a PhD in nutrition, and who helps patients fix their d…