Comment · Fri, June 21, 2013
MDMA Supplementation
Original post in this thread
MisterYouAreSoDumb · 205 points
Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory about MDA metabolism being the main cause of MDMA's neurotoxic effects. I will try to not get into that in this post, and keep this mostly about supplementation. As seems to be the norm with me, this may be long winded. Obviously everything I put on this list is not necessary. I will be placing supplements into different categories, with reasonings and references. I will let you decide which ones will be a part of your regimen.
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Essential Supplements:
* Alpha Lipoic Acid- This is one that everyone should be taking. It is a powerful antioxidant that scavenges reactive oxygen and nitrogen species. It also has a nice benefit of regenerating other vitamins, like C, after redox cycling. It exists in two enantiomers, R-ALA and S-ALA. R-ALA is the biologically active isomer that we are looking for. Most supplements a…
What they were answering
important_human · 1 points
How significant is the MDMA plasma blood level increase resulting from Grapefruit Juice intake? How much would you recommend curbing MDMA dose intake as a result? Would a 125-150mg dose be fine?
Do you have any preferred methods of ingestion among sublingual, oral, and rectal? I'm assuming not, but is is the metabolism process different for method of ingestion or is it the same for all of them?
Any other recommended sleep supplements instead of Melatonin if it is not available?
Rollsafe.org asserts: "Removed Grapefruit juice as a suggestion due to a University Professor's comment that although the MDMA to MDA conversion will be slower, the MDA breakdown may also be slowed, which could lead to potential cardiovascular or liver problems." -- Do you think this is incorrect? It seems the metabolising process is MDMA broken down by CYP3A4 to MDA, then MDA broken down by CYP2D6 to HHA (which is neurotoxic). I don't understand why this would prevent liver or cardiovascular risks.
What levels of body temperature are a danger?
Thanks a lot!
u/MisterYouAreSoDumb
Rollsafe made their page off my supplement guide. He does not know the pharmacology of it. He just merely made my guide, along with some other people's guides, into an easier to read format. Whoever that "professor" is does not know what he is talking about.
The grapefruit juice would most likely not increase peak plasma levels too much. However, it will increase the area under the curve, since it will extend it outward. If you were to take piperine and grapefruit juice (CYP2D6 and CYP3A4 inhibition), then you would see higher peak plasma concentrations. That would be preventing most of the metabolism.
A 125-150mg dose is perfect, assuming you have pure MDMA.
Any increase in body temperature over normal is going to put you at risk. Ideally you want the room temperature to say constant around 70*F. Mice kept in rooms over 80*F showed higher damage. However, that is without supplementation. With my regimen, it's going to give you more leeway.