MDMA Supplementation

Comment · Wed, March 13, 2013 · 1 pts

The mechanism for GFJ inhibition of CYP3A4 is not due to quercetin, as the levels are low. The main cause of GFJ induced inhibition is a furanocoumarin called 6',7'-dihydroxybergamottin, where it actually degrades the CY

Comment · Wed, March 20, 2013 · 2 pts

>The study you referred to contains this illustration which seems to imply that CYP1A2 and CYP2D6 play a bigger role Wow, that's an oversight on their part. They have the figure backwards!! The primary route of metaboli

Comment · Sat, March 23, 2013 · 2 pts

Sure, it plays a role. However, there is not reason to alter the dosage of your supplements. Calculating the differences would be too complicated.

Comment · Sun, March 31, 2013 · 1 pts

Unfortunately, piperine is a CYP2D6 activator. That would lead to more O-demethylation.

Comment · Mon, April 1, 2013 · 1 pts

You know I thought I had one, but I cannot seem to find it now. After doing some more searching I think it has very little CYP2D6 activity. >I was under the impression that the O-demethylation route was safer than N-dem

Comment · Thu, April 4, 2013 · 2 pts

It would do nothing. MDA is not metabolized by CYP3A4. You could try taking a CYP2D6 inhibitor. Since you are already taking MDA, there would be no risk. You might have to lower your dosage, though. Fluoxetine is a stron

Comment · Thu, April 4, 2013 · 2 pts

After the massive dump of 5-HT that MDMA induces, your stores will be so low as it is. Taking both Prozac and 5-HTP should not be an issue, so long as you only take one Prozac dose. Don't keep taking Prozac the following

Comment · Fri, April 5, 2013 · 1 pts

I tried a little experiment with some black pepper. I took 20 or so whole black pepper kernels with my kratom to see how well the CYP3A4 inhibition worked. I also took my grapefruit juice like I normally do. Holy hell di

Comment · Tue, April 9, 2013 · 1 pts

I use that one as well. It's a great liver protector.

Comment · Tue, April 9, 2013 · 1 pts

The N-methyl glutathione/NAC conjugates of MDMA are not found in the brain after dosing. However, they are found in the liver, and cause damage there. The glutathione conjugate of HHA is found in the brain after MDMA dos

Comment · Tue, April 9, 2013 · 1 pts

I am not 100% certain either way. It has the possibility of increasing the toxic metabolites, but it also has the possibility of negating them. I do not think it is a necessary supplement unless you are taking another su

Comment · Wed, April 10, 2013 · 1 pts

Ohh, then I would stay on it. If you are seeing results, keep using it.

Comment · Wed, April 10, 2013 · 1 pts

NMDA receptor antagonists are the best way. Memantine and DXM have both been shown to slow or reverse tolerance. You can also take piracetam with your MDMA to bring back the magic.

Comment · Wed, April 10, 2013 · 1 pts

I have not seen it used in that regard, however it might work.

Comment · Fri, April 12, 2013 · 2 pts

No, not really. Some people get mild depression due to the serotonin stores being depleted. For them the EGCG and 5-HTP can help get things back to normal quicker. If you are taking reasonable doses you should be fine wi

Comment · Tue, May 14, 2013 · 1 pts

You'll probably be fine. The damage from low doses of pure MDMA will most likely be negligible. It's when you start getting to higher doses, elevating your body temperature, or mixing in amphetamine that damage gets to b

Comment · Tue, May 14, 2013 · 2 pts

I err on the side of caution. At the very least, get ALA, magnesium, EGCG, and vitamin C.

Comment · Thu, May 30, 2013 · 1 pts

Usually 150mg with a 75mg redose.

Comment · Fri, June 14, 2013 · 7 pts

That has horrible bioabailability, and will make you shit yourself.

Comment · Mon, June 17, 2013 · 1 pts

Awesome! The afterglow is the best part! What magnesium did you use. Certain forms can cause diarrhea. If it was glycinate, then you might need to look into another form like L-threonate.

Comment · Fri, June 21, 2013 · 2 pts

Rollsafe made their page off my supplement guide. He does not know the pharmacology of it. He just merely made my guide, along with some other people's guides, into an easier to read format. Whoever that "professor" is d

Comment · Fri, June 21, 2013 · 1 pts

Grape seed oil will not work, as the antioxidants are not really soluble in lipids. You need a solvent extract of the seed, not cold pressed like the oil is.

Comment · Sat, June 22, 2013 · 1 pts

I usually just do oral administration. I have a sushi dinner about 5 hours before, then drop on an empty stomach with some Tums. I've never worked up the gumption to stick it up the rear. I have snorted it before, when I

Comment · Sat, June 22, 2013 · 1 pts

It's not super critical. Usually 1-2 hours before the roll.

Comment · Wed, August 21, 2013 · 2 pts

I would not suggest rolling multiple days in a row. You are going to be causing much more damage than one roll, and your effects will not be even close to the same. I would suggest finding a different substance for days

Comment · Wed, August 21, 2013 · 3 pts

Usually I start with MDMA on day one, then move to other substances for the other days. I am going to Vegas on a bachelor party in a couple weeks. Night one will be MDMA, the next day will be kratom, that night will be e

Comment · Fri, August 23, 2013 · 1 pts

Perhaps some. However, I would need to do more research. ALA is damn good, so I am not sure we need to add another ROS scavenger in there. We have to be careful of antioxidants turning pro-oxidant, as they can sometimes

Comment · Fri, August 23, 2013 · 1 pts

I just eat a big sushi dinner before my rolls. Salmon has the highest concentration of astaxanthin in nature.

Comment · Wed, August 28, 2013 · 3 pts

I've already commented on this a few times. However, I comment too much to be able to go back and find them. You most definitely want to stop **ALL** metabolism. Saying that you should take that step out because it slow

Comment · Thu, August 29, 2013 · 1 pts

Yes, because you want to excrete the MDMA unchanged before it has a chance to metabolize. EGCG helps with the vasopressin release.

Comment · Fri, August 30, 2013 · 2 pts

Piperine has very little MAOI inhibition. It's around 1,000 times less than segeligine.

Comment · Fri, August 30, 2013 · 1 pts

Milk thistle should work somewhat as well. I am not sure how potent it is, though. I am a little concerned about the piperine, as I do not know how much it will increase peak plasma levels. There is really only one way t

Comment · Mon, September 2, 2013 · 2 pts

Keep in mind that NAC need to be taken BEFORE any alcohol is consumed, or it can turn pro-oxidant. Don't take it at he end of the night.

Comment · Mon, September 2, 2013 · 1 pts

I usually redose at 1hr in, with half my initial dose. That gives me 6 hours. No redose and it's usually 4-5 hours.

Comment · Mon, September 2, 2013 · 1 pts

Hey, I did the piperine thing this weekend. I am not sure what happened, but it must have blocked an absorption pathway. It took over 2 hours for my MDMA to hit on an empty stomach, then only lasted 2 hours or so. I have

Comment · Tue, September 3, 2013 · 2 pts

Yeah, it was completely opposite of what I thought would happen. Very strange... Ohh, and I got a little sadness 40 or so hours after my roll, which lasted a couple hours. That never happens to me.

Comment · Tue, September 3, 2013 · 1 pts

I'd definitely hold off till I figure out what happened.

Comment · Thu, September 5, 2013 · 2 pts

> astaxanthin I don't see anything obvious that would be harmful. It could be a good addition as an antioxidant. I'm not certain of it's effect on the roll experience, though.

Comment · Fri, February 7, 2014 · 3 pts

I think I figured out it was an interaction with the SAMe that I had earlier in the day. I had been on a SAMe regimen for a few weeks, and did not think of possible interactions. Since SAMe affects the serotonin system,