Comment · Tue, February 10, 2015 · Ceretropic
New at THT.co
Original post in this thread
kanooker · 41 points
Crebinostat
http://www.tht.co/cognitive-enhancement/Crebinostat
>Crebinostat is a potent small molecule inhibitor of histone deacetylases (HDACs).
HDAC inhibition upregulates the transcription factor CREB (cAMP response element-binding protein), which can improve memory and synaptic plasticity.
In a series of in vitro experiments, Crebinostat positively affected several transcriptional processes implicated in learning and memory, and aging-related cognitive decline. In an in vitro animal experiment, Crebinostat-treated mice demonstrated enhanced memory compared to untreated mice.
CNTF Peptide Fragment 147-150
http://www.tht.co/cognitive-enhancement/cntf
is a tetrapeptide that corresponds to amino acid residues 147-150 of the polypeptide hormone ciliary neurotrophic factor (CNTF). CNTF is neuroprotective and promotes neurogenesis in the hippocampus, but clinical use revealed unpleasant side-effects like substantial weight and muscle loss. The CNTF fragment 147-150 (DGGL) enhances hippocampal neurogenesis and neuronal plasticity, and improves cognition in mice, without the weight loss seen with CNTF administration.
F2MPA
What they were answering
hackallthethings · 2 points
So... we need either a reference sample or reliable reference data to compare with? I'd be willing to chip in and I suspect others might too. You guys seem to have lab connections so could it be possible to order a small amount as reference from Sigma Aldrich?
It might even be possible to just ask SA for HPLC data as it should be available since they list GTS-21 as in stock along with a claimed purity. It seems reasonable that they would present some data upon request to prospective customers to back up their purity claim.
Feel free to correct any mistaken assumptions I might have made, just looking for a way forward here as THT hasn't given us any more info yet.
u/MisterYouAreSoDumb · Ceretropic
Ohh shit, Sigma has it. Then it will be no problem to test. We have an account with Sigma, and our lab uses them all the time for reference samples.