Comment · Fri, February 6, 2015 · Ceretropic
New at THT.co
Original post in this thread
kanooker · 41 points
Crebinostat
http://www.tht.co/cognitive-enhancement/Crebinostat
>Crebinostat is a potent small molecule inhibitor of histone deacetylases (HDACs).
HDAC inhibition upregulates the transcription factor CREB (cAMP response element-binding protein), which can improve memory and synaptic plasticity.
In a series of in vitro experiments, Crebinostat positively affected several transcriptional processes implicated in learning and memory, and aging-related cognitive decline. In an in vitro animal experiment, Crebinostat-treated mice demonstrated enhanced memory compared to untreated mice.
CNTF Peptide Fragment 147-150
http://www.tht.co/cognitive-enhancement/cntf
is a tetrapeptide that corresponds to amino acid residues 147-150 of the polypeptide hormone ciliary neurotrophic factor (CNTF). CNTF is neuroprotective and promotes neurogenesis in the hippocampus, but clinical use revealed unpleasant side-effects like substantial weight and muscle loss. The CNTF fragment 147-150 (DGGL) enhances hippocampal neurogenesis and neuronal plasticity, and improves cognition in mice, without the weight loss seen with CNTF administration.
F2MPA
What they were answering
sowhatquestion · 3 points
Has anyone tried GTS-21? I've had my eye on it ever since it was discussed on Longecity. On paper it looks amazing... I would feel better about forking over the $$$ if I could hear some anecdotal reports though.
Do THT people hang around here? Do they take stuff themselves the way, e.g., /u/MisterYouAreSoDumb does?
u/MisterYouAreSoDumb · Ceretropic
The only link I have to what is going on with THT is /u/redan-yadayada's updates. I don't think they even try their own stuff, or post anything here. They are a lab based out of Hong Kong, which is how they are able to bring some of these out.