Comment · Sat, February 7, 2015 · Ceretropic
New at THT.co
Original post in this thread
kanooker · 41 points
Crebinostat
http://www.tht.co/cognitive-enhancement/Crebinostat
>Crebinostat is a potent small molecule inhibitor of histone deacetylases (HDACs).
HDAC inhibition upregulates the transcription factor CREB (cAMP response element-binding protein), which can improve memory and synaptic plasticity.
In a series of in vitro experiments, Crebinostat positively affected several transcriptional processes implicated in learning and memory, and aging-related cognitive decline. In an in vitro animal experiment, Crebinostat-treated mice demonstrated enhanced memory compared to untreated mice.
CNTF Peptide Fragment 147-150
http://www.tht.co/cognitive-enhancement/cntf
is a tetrapeptide that corresponds to amino acid residues 147-150 of the polypeptide hormone ciliary neurotrophic factor (CNTF). CNTF is neuroprotective and promotes neurogenesis in the hippocampus, but clinical use revealed unpleasant side-effects like substantial weight and muscle loss. The CNTF fragment 147-150 (DGGL) enhances hippocampal neurogenesis and neuronal plasticity, and improves cognition in mice, without the weight loss seen with CNTF administration.
F2MPA
What they were answering
redan-yadayada · 2 points
Yes, I got their new batch and it smells different from the HCL suspension. It just smells synthetic, best way to describe it. But, I'm near certain it has positive effects. I know that the effects are cumulative. Personally, I think Bromantane would be ideal for defeating depression.
u/MisterYouAreSoDumb · Ceretropic
We have samples going to the lab, so we'll figure it out. I will keep on my trial of Bromantane, and see if the cumulative effects stack up. The research does look pretty cool; especially the tyrosine hydroxylase expression.