Comment · Sat, February 7, 2015 · Ceretropic
New at THT.co
Original post in this thread
kanooker · 41 points
Crebinostat
http://www.tht.co/cognitive-enhancement/Crebinostat
>Crebinostat is a potent small molecule inhibitor of histone deacetylases (HDACs).
HDAC inhibition upregulates the transcription factor CREB (cAMP response element-binding protein), which can improve memory and synaptic plasticity.
In a series of in vitro experiments, Crebinostat positively affected several transcriptional processes implicated in learning and memory, and aging-related cognitive decline. In an in vitro animal experiment, Crebinostat-treated mice demonstrated enhanced memory compared to untreated mice.
CNTF Peptide Fragment 147-150
http://www.tht.co/cognitive-enhancement/cntf
is a tetrapeptide that corresponds to amino acid residues 147-150 of the polypeptide hormone ciliary neurotrophic factor (CNTF). CNTF is neuroprotective and promotes neurogenesis in the hippocampus, but clinical use revealed unpleasant side-effects like substantial weight and muscle loss. The CNTF fragment 147-150 (DGGL) enhances hippocampal neurogenesis and neuronal plasticity, and improves cognition in mice, without the weight loss seen with CNTF administration.
F2MPA
What they were answering
cobue · 2 points
I had original Ladasten from Russia which was highly effective and with no tolerance issues. I won´t notice anything on THTs Bromantane, nothing, at any dosage. Got after 4 weeks of ineffective, original Ladasten again, and it had the known effect. It seems that there is an ineffective batch at tht. On the other hand i have never had any issues with tht.co and have always been pleased by their service and quality, but this is a little strange. I would be willing to send some Milligrams for testing if necessary.
Edit: Wrote an email to tht.co their answer was that the compound was tested "very stringently"
u/MisterYouAreSoDumb · Ceretropic
Yeah, send me some. I noticed nothing on their latest batch of Bromantane. Plus, the smell is a bit disconcerting. It's a very unique smell.