Comment · Sat, February 7, 2015 · Ceretropic
New at THT.co
Original post in this thread
kanooker · 41 points
Crebinostat
http://www.tht.co/cognitive-enhancement/Crebinostat
>Crebinostat is a potent small molecule inhibitor of histone deacetylases (HDACs).
HDAC inhibition upregulates the transcription factor CREB (cAMP response element-binding protein), which can improve memory and synaptic plasticity.
In a series of in vitro experiments, Crebinostat positively affected several transcriptional processes implicated in learning and memory, and aging-related cognitive decline. In an in vitro animal experiment, Crebinostat-treated mice demonstrated enhanced memory compared to untreated mice.
CNTF Peptide Fragment 147-150
http://www.tht.co/cognitive-enhancement/cntf
is a tetrapeptide that corresponds to amino acid residues 147-150 of the polypeptide hormone ciliary neurotrophic factor (CNTF). CNTF is neuroprotective and promotes neurogenesis in the hippocampus, but clinical use revealed unpleasant side-effects like substantial weight and muscle loss. The CNTF fragment 147-150 (DGGL) enhances hippocampal neurogenesis and neuronal plasticity, and improves cognition in mice, without the weight loss seen with CNTF administration.
F2MPA
What they were answering
redan-yadayada · 3 points
Yeah, the cool thing about bromantane is that it does this through epigenetic changes rather than acute effects of the drug on neurotransmitter levels like SSRI's and SNDRI's. So, you don't really get any withdraws from not taking it or low moods. Also, since the plasma levels are pretty constant (~10 days), given the adamantane backbone, it's effects are consistent and not dependent on immediate drug administration. Just some cool facts.
u/MisterYouAreSoDumb · Ceretropic
Have you gotten any GI upset with Bromantane?