Comment · Wed, August 6, 2025 · ND Owner
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NDSocialMedia · 74 points
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What they were answering
lewanay · 3 points
The effects of Berberine are similar to metformin. Do you worry about the exercise blunting effects like with Merformin? I had to stop taking it for that reason
u/MisterYouAreSoDumb · ND Owner
How did you measure its effects on exercise? Did you see significant issues there? The main difference between metformin and berberine in this area are multifold. One, metformin's negative effects are linear in a dose/response sense. This means that the side effects are consistent at all doses, and just go up as the dose gets higher. Berberine has a biphasic dose/response curve. This means that while higher doses of berberine can inhibit muscle growth, more reasonable ones should not. In fact, lower doses of berberine can have a positive effect there.
So it depends on what dose you are taking of berberine. I take our Berbelean every day in the morning, and just take it once a day. That works well for me. I am also taking some other muscle supporting supplements like epicatechin, so I don't see any issues with exercise and muscle growth. However, if I was taking Berbelean multiple times a day, or taking regular berberine 3X per day like some people do, that might be a different story.