Comment · Mon, August 4, 2025 · ND Owner
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NDSocialMedia · 74 points
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What they were answering
ArcticPlatypus · 3 points
I was also just reading this same paper I think you’re referencing about the FAAH inhibition vs Anandamide (AEA) reuptake inhibition with CB1 and CB2 receptor measurements as well. You’re definitely right, they found compound 7, a macamide- to have 0.67 micro molar affinity as an AEA reuptake inhibitor vs 4.07 micro molar at FAAH inhibition, with its most potent activity being 0.48 micro molar at CB1.
https://pubs.acs.org/doi/10.1021/np500292g
Here’s the thing though, what dose of this macamide 7 is contained within the 5% macamide extract? And how much would one need to intake to reach that concentration. Very difficult to even say what dose would be needed to reach .48 micro molar and beyond. May need even higher doses than the 6 capsules you tried to have super significant effects. I’ve been digging into papers to try and get rough ideas on what doses of things are needed and it is tough to determine without animal or human studies.
u/MisterYouAreSoDumb · ND Owner
That's the issue. Without direct human pharmacokinetic data, we can only postulate what dose it takes to reach that plasma concentration. We know the mechanism is there. We can use that data to inform how/why we might be responding a certain way. However, a lot more data is needed to prove it.
In that paper, macamide 7 is N-benzyl-(9Z,12Z)-octadecadienamide. We refer to that as Macamide C. That's the highest concentration macamide in our extract, with 3.34% concentration in our extract. So while we don't know the exact dose needed to reach the same plasma concentrations in the study, we know it is the highest macamide in our extract, and that macamide has FAAH inhibition effects.