Comment · Sat, January 22, 2022 · ND Owner
NMN formulation change
Original post in this thread
ROTHUM2 · 38 points
Has anyone else noticed a difference in efficacy between the old NMN tablets (sized like a small cylinder) versus the new one (sized like a small disc)?
I thought it was placebo at first, but with the old NMN, I noticed a profound increase in energy and well being. With the new NMN (disc shape), I notice nothing.
Thinking I may be tricking myself, I experimented on my wife. When I give her the old NMN, her energy noticeably improved. When I give her the new one, no difference.
I’m curious if anyone else has had this experience. I know /u/MisterYouAreSoDumb has mentioned the enteric coating on the new NMN is superior, but I can’t help but notice my consistent, personal experience.
UPDATE (Feb 2022)
They must have gone through several iterations, because the magic is back on my latest purchase. I’ve seen 3 different tablets — the cylinder (original), a larger flat circle with a powdery exterior, and the most recent, a smaller circle with a smoother exterior.
The only version that didn’t work for me was the one with the powdery exterior. The newest version works GREAT, perhaps even better than the original.
What they were answering
solothesensei · 6 points
Yeah! We partner with this company that does 3D printing of polypill formulations for hospitals. We're actually their first non-medical client. For an R&D fee, they created an excipient mix for our product.
There are two print heads on the special machine they developed - one prints our formula + the mix (to slow down the release profile to our specifications, and to allow for adequate hardening after printing). The other prints a layer of the pure excipient mix on top of the pill to get the enteric property. It's a bit inefficient at the moment though - hard to scale beyond several thousand pills unless they buy more machines. On the bright side, our government seems interested in the additive manufacturing industry so it'll be quite easy to get grants and subsidies for scaling up.
u/MisterYouAreSoDumb · ND Owner
That's pretty cool! There is a lot of potential in controlled-release matrices in formulations. I suppose 3D printing them is a way to do it. Once the scaling challenges are overcome, it could be a cool system!