Comment · Sun, February 20, 2022 · ND Owner
NMN formulation change
Original post in this thread
ROTHUM2 · 38 points
Has anyone else noticed a difference in efficacy between the old NMN tablets (sized like a small cylinder) versus the new one (sized like a small disc)?
I thought it was placebo at first, but with the old NMN, I noticed a profound increase in energy and well being. With the new NMN (disc shape), I notice nothing.
Thinking I may be tricking myself, I experimented on my wife. When I give her the old NMN, her energy noticeably improved. When I give her the new one, no difference.
I’m curious if anyone else has had this experience. I know /u/MisterYouAreSoDumb has mentioned the enteric coating on the new NMN is superior, but I can’t help but notice my consistent, personal experience.
UPDATE (Feb 2022)
They must have gone through several iterations, because the magic is back on my latest purchase. I’ve seen 3 different tablets — the cylinder (original), a larger flat circle with a powdery exterior, and the most recent, a smaller circle with a smoother exterior.
The only version that didn’t work for me was the one with the powdery exterior. The newest version works GREAT, perhaps even better than the original.
What they were answering
[deleted] · 2 points
[deleted]
u/MisterYouAreSoDumb · ND Owner
Exactly. People are blowing things out of proportion based on rat studies that they are misinterpreting. There is a really big problem in both science and the media pushing narratives and trying to release ground-breaking data to get clicks and hype.
Both thyroxine and berberine inhibit CYP3A4, but I am not sure if that will cause any real interaction. I'd have to look at the affinities of each. Berberine is a great metabolic supplement.