Comment · Sat, February 7, 2015 · Ceretropic
Why do I feel so great after dosing icariin?
Original post in this thread
[deleted] · 15 points
I've noticed that, since starting occasional consumption of 500-750 mg of Icariin (40% from powdercity) - that I feel great! I feel confident, pro-social, my brain fog appears to lift and I can empathize with people easier. I originally got it for some intimate moments, but didn't think it would feel like an anti-depressant. To clarify, I've used this occasionally since two months ago, and whenever I use it, I get those effects. There appears to be tolerance if I use it everyday for a week though.
What is the mechanism? Does it increase dopamine/serotonin?
Other information:
I don't respond to MACA, aniracetam, pramiracetam is iffy, I respond to high-doses of piracetam, and noopept puts me in a weird headspace.
Here is what I found:
http://www.sciencedirect.com/science/article/pii/S0091305705003709
It is behind a paywall, so I've uploaded the paper here. http://www.docdroid.net/r373/1-s20-s0091305705003709-main.pdf.html
I may edit this with my summary of that paper.
Summary:
Introduction (this is study done on rats)
In depressed patients, the hypothalamic-pituitary-adrenal (HPA) axis is impaired. Corticotropin releasing factor (CRF) acts to regulate the HPA. These scient…
What they were answering
Debonaire_Death · 1 points
I also react very poorly to vasoconstriction.
This has been a kicker for me, since I used to be an avid consumer of psychedelics. I just can't take the abuse anymore, though. Still, having to moderate usage has led to me selecting much better occasions for it. I can't smoke cigarettes very often, either (bummer, right? haha) without making things worse.
L-citruline and other NO*'2'* boosters seem to help, but only temporarily--which is worth it if you aren't going out into the cold.
I think I'm going to carry L-citruline with me from now on.
u/MisterYouAreSoDumb · Ceretropic
The L-Citruline/L-Arginine combo works pretty well for me. I always take them with substances that can lead to vasoconstriction.