Comment · Wed, June 18, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
Rsorey · 2 points
New Reishi products=Red Reishi 1:1 + CO2 Reishi Spore Oil +Red Reishi 9% ?
u/MisterYouAreSoDumb · ND Owner
Yeah, that stack will be out very soon. We actually used a 14% in it, not the 9%. We also didn't do a supercritical CO2 extract of the spores. That always comes out as an oil. We did whole cracked spore powder. It's a similar process to how they do broken cell chlorella. It's breaking open the cell walls of the spores to release all the actives, but you are keeping the full spectrum of actives intact. You lose some in the supercritical CO2 process.