Comment · Sat, June 14, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
Rsorey · 2 points
Every time I see your passionate comments,you leave a deep impression on me,You have been seriously trying to wake people up, I admire very much.About mushroom products, I have been wanting to ask you some questions. Can you answer them?Why does ND choose the fruiting body of turkey tail instead of the mycelium(liquid)?Based on my investigation, it seems that I cannot find any clinical studies on the fruiting body of turkey tail mushrooms,(If available, please feel free to send me the link)At present, clinical research on turkey tail mushrooms is conducted using mycelium(liquid),That is to say, you are actually selling products that have not received clinical research support,Although your turkey tail mushroom fruiting body products have high levels of β-glucan,Therefore, it should have a good effect.But in my heart, ND is the supplement company that I consider the most trustworthy,Because I found that you, like me, are obsessed with finding the best raw material on world,To be honest, I don't quite understand why you haven't chosen turkey tail mushroom mycelium with clinical research support.
u/MisterYouAreSoDumb · ND Owner
There is research on the fruiting bodies.
https://www.liebertpub.com/doi/abs/10.1089/jmf.2006.9.175
However, you are right. There is more research on the mycelium of Turkey Tail. The issue to this point is that we have not had a source of pure mycelium for that species. We spent most of our efforts developing Erinamax for Lion's Mane, along with optimizing Reishi and Cordyceps. The reason for that is twofold. One, those are the most popular and fastest selling species. This means it is easier to justify the costs that go into optimizing them. Two, turkey tail is seen as a drug by Google, causing tons of disapprovals on ads. This includes ads for other products where turkey tail even shows up on the page, or in the menu. It's been a big headache for us. This is why we have not put a lot of time, effort, or money into going down the liquid culture route for Turkey Tail. We have to prioritize our scientific efforts for what makes the most sense.