Comment · Fri, June 13, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
Warren_sl · 2 points
I may regret ordering the product, lol. I just wanted to try it to put my years long curiosity to rest. Have you tried or looked into the Maritech Fucoidan extract products?
u/MisterYouAreSoDumb · ND Owner
I have not looked into them yet. I'll see about reaching out. They claim to have highly characterized the fucoidans, so maybe they have made better methods for them. I just want to really be confident in the science before I go down a path like that again.
Also, to be clear, I don't think beta-glucans as a whole are all BS. If we could have methods to properly separate and characterize the specific 1,3 and 1,6 beta-glucans in the various mushrooms, those have shown benefits. We have worked on that in the background. It's just a lot harder than it seems. Size exclusion chromatography with secondary analysis via NMR seems like the best possible way. However, nobody is really doing that yet, and the equipment is very expensive. Perhaps one day we will.