Comment · Fri, June 13, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
realleg29 · 1 points
https://imgur.com/a/e3pYQWy \- this is the one posted on their website. u/Warren_sl could you share the one they sent you?
u/MisterYouAreSoDumb · ND Owner
Yep, as I thought. That's not a COA that I would put any stake in. It's a UV-VIS method to quantify fucoidan. It's not scientifically valid. I can go into the chemistry if you want, but it will be complex. Also, that lab seems sketch. They claim ISO accreditation, but I can't find their cert anywhere. Not saying they 100% aren't, but where is the cert? Who is the accreditation body? What's on their scope?