Comment · Sat, June 14, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
Warren_sl · 2 points
That’s awesome, I often have a can of beans and a can of tuna mixed together with seasonings for lunch, might have to switch to black beans from bean trio. Black beans also contain anthocyanins!
u/MisterYouAreSoDumb · ND Owner
Pretty cool, right? I am just working really hard in the background to help the industry move away from this idea that all alpha-glucans are bad and all beta-glucans are good. It's always much more complex than everyone makes it seem. Pair that with the absolute insane amounts of adulteration in the mushroom market using beta-glucans from yeast, and you can get an idea of just how many consumers are being misled right now.