Comment · Mon, June 16, 2025 · ND Owner
Anthocyanin-fucoidan nanocomplex
Original post in this thread
Warren_sl · 10 points
I thought this would be an interesting thing to share. Unsure if stacking Fucoidans and anthocyanins confer any similar benefit or not, but this could be an interesting product type to look into. Curious on its modulation of SIRT6 considering the affinity both Fucoidans and Anthocyanins have for it.
“Abstract
Anthocyanins, commonly extracted from aronia, exhibit excellent in antioxidant activity and anti-cancer activity. However, anthocyanins are not only easily oxidized in water but also rapidly disappear from the body, thus requiring a large amount of administration. To solve these limitations, we selected fucoidan, an anionic polymer, to produce an anthocyanin-fucoidan nanocomplex (AFNC) with enhanced absorption and chemical stability by ionic bonding and π-π stacking between anthocyanins. In vitro, AFNC showed increased cell permeability absorption and plasma chemical stability than free anthocyanins. AFNC suppressed the epithelial mesenchymal transition (EMT) signal including IκBα/NF-κB signaling pathway and the release of pro-inflammatory cytokines. In vivo, AFNC exhibited 3.24-fold higher bioavailability than free anthocyanin in rats. AFNC effectively suppressed the gene…
What they were answering
[deleted] · 1 points
[deleted]
u/MisterYouAreSoDumb · ND Owner
Yes, all the cancer clinical trials on Turkey Tail are on the mycelium. Also, it's not just the mycelium. It's a very specific extract of a liquid culture of the mycelium from one specific company. Again, it's not that I disagree that Turkey Tail mycelium seems to be the most studied and interesting. It's just a regulatory/policy headache for it, and there are no non-pharmaceutical sources for it.
If you only choose one of your mushroom products to maximize immune support, which mushroom do you think has the best effect?
Reishi standardized to ganoderic acids. I'd actually say our upcoming optimized Reishi stack, but that is not out yet.