Comment · Thu, June 2, 2022
Ketamine induced neurotoxicity
Original post in this thread
multiple_sclerotia · 31 points
I notice a lot of people describing ketamine as a real benign substance, which doesn't cause any neuronal damage. Sure, the increased BDNF caused by low dosing seems to check out and seems like a beneficial aspect to mental/cerebral health, but I've recently come across some studies proving ketamine induces apoptosis in rats and monkeys.
The theory behind this, if I understand it correctly, is an overexpression of NR1 receptors, causing a higher calcium influx leading to oxidation and subsequently apoptosis, or neuronal death.
The article also states this damage might be evaded by supplementing with L-Carnitine. (Maybe any antioxidant would be fine? I have no idea)
Of course, this has never been proven in humans. That doesn't mean it doesn't happen like this in humans. For me, it's a cause for concern, and I would like you drugnerds to shed light on the issue. What is your opinion of these articles?
Note: I have very little knowledge on this subject and just found out about this mechanism. If any of you can explain it better, please do, because I don't fully understand it and think you guys can explain it way better.
What they were answering
SelfAugmenting · 1 points
Any way to reverse this damage?
u/MisterYouAreSoDumb
Actual ketamine-induced neurotoxicity is from neuronal cell death, so recovering from that is difficult. I would say things that increase/mimic NGF and BDNF would be the best bet. That would be 7,8-dihydroxyflavone, lion's mane, polygala, etc.