Comment · Wed, August 12, 2020 · ND Owner
Immune Defense & positive blood test results
Original post in this thread
solothesensei · 10 points
Hi ND team and u/misteryouaresodumb, a few months ago I started taking ND's Immune Defense. I also took two blood tests near the start and end of the bottle.
Interestingly, the scores on my WBC differential count improved quite significantly, especially with respect to lymphocytes (went from 2.5x10\^9 to 3.6x10\^9 per liter). I understand these include the NK cells, T cells and B cells.
This seems positive but can immunity be actually quantified by these numbers on a blood test? In any case, you guys are doing amazing work. Thank you for all that you do.
What they were answering
umbrella_term · 2 points
So leptin and testosterone are negatively correlated with each other. If testosterone goes up, leptin goes down, and vice versa. Lower leptin and increased testosterone are correlated with fat loss
Emphasis mine. This seems contradictory at a surface level, since leptin inhibits hunger. I suppose it's just a matter of the interactions being way more complex than what I just said?
u/MisterYouAreSoDumb · ND Owner
Sorry, I must have missed your comment.
So yes, leptin does inhibit hunger. However, the issue is leptin sensitivity. It's just like insulin. Too much insulin causes insulin desensitization, which is bad. The same goes for leptin. Obese people have leptin resistance. So lowering leptin helps to increase leptin sensitivity, which increases fat loss. Berberine has a similar effect.
It also appears that a cytokine suppressor called Socs3 is part of the story with leptin sensitivity.
So while leptin does inhibit hunger, you can become resistant to it just like insulin. So lowering those levels can help improve leptin sensitivity, which improves fat loss.