Significant depression/anxiety from 7,8-dihydroxyflavone. High BDNF thoughts?

Comment · Wed, December 13, 2017 · 5 pts

There's a reference standard for 7,8-DHF. There's no reference standard for 5,7,8-THF, which is what we think we got. We worked with Colmeric to confirm the supply at the time was not 7,8-DHF, using the Sigma reference m

Comment · Wed, December 13, 2017 · 3 pts

At the time this was the case. Everyone was selling 7,8-DHF that did not match Sigma's standard. It was certainly psychoactive, though. I think it was 5,7,8-trihydroxyflavone, which has very similar affinities to 7,8-DHF

Comment · Wed, December 13, 2017 · 5 pts

Holy shit, that's new! Everyone we contacted a few months back said they did not have it. We work with Alkemist every week. So I'll get some from them and we can finally confirm things. Thanks for letting me know!

Comment · Thu, December 14, 2017 · 4 pts

For sure. If I can verify it's really 5,7,8-THF, I have no problem selling that. Similarly, if I can find actual 7,8-DHF, I'll sell that as well.

Comment · Thu, December 14, 2017 · 3 pts

Probably not. That's going to be another one like NSI-189, where the patent holder defends it pretty heavily. There are also no reference standards. So developing methods will be pretty costly.

Comment · Thu, December 14, 2017 · 5 pts

It was a nice mood boost that lasted maybe an hour or so.

Comment · Fri, December 15, 2017 · 2 pts

I think we reached out to them before, and they said they actually did not have it. I will check with my team.

Comment · Sat, December 16, 2017 · 3 pts

I just bought some from BBB. It should be here soon. I will run it through the lab. Also, the Colmeric COA on their site is from May 2016. The Chinese COA they have as a picture on that page shows the current batch as

Comment · Mon, December 18, 2017 · 1 pts

They are TrkB agonists, which is the main signaling receptor of BDNF (brain derived neurotrophic factor).