Comment · Wed, December 13, 2017 · Ceretropic & Nootropics Depot
Significant depression/anxiety from 7,8-dihydroxyflavone. High BDNF thoughts?
Original post in this thread
ReadWhat123 · 11 points
I'm seeing a significant ~"sinking" depression/anxiety with typical dosages of 7,8-dihydroxyflavone. This is counter to its intended purpose, but not out of the realm of rationality — we lust after BDNF promoting substances, but there is a line of inquiry suggesting high/up-regulated BDNF/TrkB (as well as low) is found in/contributes to depression (or in reality, it's just a lot more nuanced than just low/high). Problem is I've only really read one paper on the topic (https://www.nature.com/articles/4002075). I'm wondering if anyone has this as an area of interest/would like to expound?
What they were answering
bojee123 · 5 points
didnt /u/MisterYouAreSoDumb say that all the available 78dhf on the consumer market wasnt actually 78dhf ?
so u cant really say what is actually happening to u . might be placebo
edit: removed edit - check the reply from him here
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
At the time this was the case. Everyone was selling 7,8-DHF that did not match Sigma's standard. It was certainly psychoactive, though. I think it was 5,7,8-trihydroxyflavone, which has very similar affinities to 7,8-DHF.
I cannot comment on the current supply of 7,8-DHF, as I have not tried to source it in a while, and I have not tested any of the current vendor's product. If Colmeric is saying it is good, then it probably is good. Colmeric were the ones that helped us confirm the stuff back then was not 7,8-DHF. So the standard and methods they are using now should be the same.