Comment · Thu, December 14, 2017 · Ceretropic & Nootropics Depot
Significant depression/anxiety from 7,8-dihydroxyflavone. High BDNF thoughts?
Original post in this thread
ReadWhat123 · 11 points
I'm seeing a significant ~"sinking" depression/anxiety with typical dosages of 7,8-dihydroxyflavone. This is counter to its intended purpose, but not out of the realm of rationality — we lust after BDNF promoting substances, but there is a line of inquiry suggesting high/up-regulated BDNF/TrkB (as well as low) is found in/contributes to depression (or in reality, it's just a lot more nuanced than just low/high). Problem is I've only really read one paper on the topic (https://www.nature.com/articles/4002075). I'm wondering if anyone has this as an area of interest/would like to expound?
What they were answering
lord_abbott · 1 points
Any chance of NRX1074, matey? TeamTLR claim to have it but you know them.
The GLYX-13/NRX1074 drugs are very promising stuff for those of us with resistant Anhedonia.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Probably not. That's going to be another one like NSI-189, where the patent holder defends it pretty heavily. There are also no reference standards. So developing methods will be pretty costly.