Significant depression/anxiety from 7,8-dihydroxyflavone. High BDNF thoughts?

Comment · Wed, December 13, 2017 · 5 pts

There's a reference standard for 7,8-DHF. There's no reference standard for 5,7,8-THF, which is what we think we got. We worked with Colmeric to confirm the supply at the time was not 7,8-DHF, using the Sigma reference m

Comment · Wed, December 13, 2017 · 3 pts

At the time this was the case. Everyone was selling 7,8-DHF that did not match Sigma's standard. It was certainly psychoactive, though. I think it was 5,7,8-trihydroxyflavone, which has very similar affinities to 7,8-DHF

Comment · Thu, December 14, 2017 · 4 pts

For sure. If I can verify it's really 5,7,8-THF, I have no problem selling that. Similarly, if I can find actual 7,8-DHF, I'll sell that as well.

Comment · Thu, December 14, 2017 · 3 pts

Probably not. That's going to be another one like NSI-189, where the patent holder defends it pretty heavily. There are also no reference standards. So developing methods will be pretty costly.

Comment · Thu, December 14, 2017 · 5 pts

It was a nice mood boost that lasted maybe an hour or so.

Comment · Fri, December 15, 2017 · 2 pts

I think we reached out to them before, and they said they actually did not have it. I will check with my team.

Comment · Fri, December 15, 2017 · 3 pts

Ohh damn, $11,400... We've never worked with Tractus Chem. Are they reputable? It looks like they are based in Hong Kong.

Comment · Sat, December 16, 2017 · 3 pts

I just bought some from BBB. It should be here soon. I will run it through the lab. Also, the Colmeric COA on their site is from May 2016. The Chinese COA they have as a picture on that page shows the current batch as

Comment · Mon, December 18, 2017 · 1 pts

They are TrkB agonists, which is the main signaling receptor of BDNF (brain derived neurotrophic factor).